Document Detail

Genetics of macrophage-controlled resistance to hepatitis induced by herpes simplex virus type 2 in mice.
MedLine Citation:
PMID:  197015     Owner:  NLM     Status:  MEDLINE    
The genetics of innate resistance of mice to hepatitis induced by herpes simplex virus type 2 (HSV-2) was analyzed by crossing resistant male GR to susceptible female BALB/c mice and backcrossing females of this F1 generation to susceptible male BALB/c mice. By scoring of macroscopic liver lesions and virus isolation studies from the liver 4 days after intraperitoneal inoculation of HSV-2, it appeared that the resistance was governed by one X-linked dominant gene or closely linked gene complex, as F1 female mice were resistant and F1 male mice were susceptible and the trait segregated in a ratio close to 1:1 in the backcross mating. A cellular expression in vitro of virus resistance was found in the macrophage population of the mice as measured by differences in the restriction of HSV-2 replication in macrophage cultures prepared from individual mice. In contrast to what was seen in macrophage cultures, virus replicated equally well in embryonic fibroblast cultures from susceptible and resistant strains of mice.
S C Mogensen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Infection and immunity     Volume:  17     ISSN:  0019-9567     ISO Abbreviation:  Infect. Immun.     Publication Date:  1977 Aug 
Date Detail:
Created Date:  1977-10-14     Completed Date:  1977-10-14     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0246127     Medline TA:  Infect Immun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  268-73     Citation Subset:  IM    
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MeSH Terms
Ascitic Fluid / cytology
Cells, Cultured
Crosses, Genetic
Fibroblasts / cytology
Genes, Dominant*
Hepatitis, Animal / genetics,  immunology*
Herpesviridae Infections / genetics,  immunology*
Liver / microbiology
Macrophages / immunology*,  microbiology
Mice, Inbred Strains
Sex Chromosomes
Simplexvirus / growth & development,  isolation & purification
Virus Replication

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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