Document Detail

Genetics of lipid traits and relationship to coronary artery disease.
MedLine Citation:
PMID:  23881580     Owner:  NLM     Status:  MEDLINE    
Despite the critical importance of plasma lipoproteins in the development of atherosclerosis, varying degrees of evidence surround the causal associations of lipoproteins with coronary artery disease (CAD). These causal contributions can be assessed by employing genetic variants as unbiased proxies for lipid levels. A relatively large number of low-density lipoprotein cholesterol (LDL-C) variants strongly associate with CAD, confirming the causal impact of this lipoprotein on atherosclerosis. Although not as firmly established, genetic evidence supporting a causal role of triglycerides (TG) in CAD is growing. Conversely, high-density lipoprotein cholesterol (HDL-C) variants not associated with LDL-C or TG have not yet been shown to be convincingly associated with CAD, raising questions about the causality of HDL-C in atherosclerosis. Finally, genetic variants at the LPA locus associated with lipoprotein(a) [Lp(a)] are decisively linked to CAD, indicating a causal role for Lp(a). Translational investigation of CAD-associated lipid variants may identify novel regulatory pathways with therapeutic potential to alter CAD risk.
Tanya E Keenan; Daniel J Rader
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current cardiology reports     Volume:  15     ISSN:  1534-3170     ISO Abbreviation:  Curr Cardiol Rep     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-07-24     Completed Date:  2014-03-11     Revised Date:  2014-09-02    
Medline Journal Info:
Nlm Unique ID:  100888969     Medline TA:  Curr Cardiol Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  396     Citation Subset:  IM    
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MeSH Terms
Biological Markers / blood
Cholesterol, LDL / blood,  genetics
Coronary Artery Disease / blood,  genetics*
Genetic Loci
Genetic Predisposition to Disease
Lipids / blood,  genetics*
Lipoprotein(a) / blood,  genetics
Mendelian Randomization Analysis / methods
Polymorphism, Single Nucleotide
Triglycerides / blood,  genetics
Grant Support
Reg. No./Substance:
0/Biological Markers; 0/Cholesterol, LDL; 0/Lipids; 0/Lipoprotein(a); 0/Triglycerides

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