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Genetics of intracranial aneurysm.
MedLine Citation:
PMID:  17903881     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Subarachnoid hemorrhage (SAH) secondary to ruptured saccular intracranial aneurysm (IA) is a complex trait, with both genetic and environmental risk factors playing an important part. The 30-day mortality rate of patients with SAH is 40% to 44%, with many survivors suffering from major disability. Because most of the mortality after SAH is caused by rapid and massive brain injury from the initial bleeding, primary prevention of aneurysm formation and rupture is of paramount importance. This article reviews the evidence supporting a genetic predisposition to SAH from saccular IA, the conditions commonly associated with saccular IA, and the search for genetic risk factors.
Authors:
Daniel Woo; Joseph Broderick
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association     Volume:  11     ISSN:  1532-8511     ISO Abbreviation:  J Stroke Cerebrovasc Dis     Publication Date:    2002 Sep-Oct
Date Detail:
Created Date:  2007-10-01     Completed Date:  2007-10-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9111633     Medline TA:  J Stroke Cerebrovasc Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  230-40     Citation Subset:  -    
Affiliation:
Department of Neurology, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0525, USA. daniel.woo@uc.edu
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