| Genetics of hypertensive syndrome. | |
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MedLine Citation:
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PMID: 19339789 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The knowledge of the genetic bases of hypertension has improved over the last decade; this area of research has high priority due to the high incidence of hypertension and its impact on public health. Monogenetic mineralocorticoid hypertension syndromes are associated with suppressed plasma renin activity due to excessive activation of the mineralocorticoid pathway. We review the pathophysiology, phenotype, and method of diagnosis for familial hyperaldosteronism type I and type II, hypertensive forms of congenital adrenal hyperplasia, 11beta-hydroxysteroid dehydrogenase type 2 deficiency, Liddle's syndrome, an activating mutation of the MR, and glucocorticoid resistance. We also review some genes that could contribute to essential hypertension. |
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Authors:
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Alejandro Martinez-Aguayo; Carlos Fardella |
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Publication Detail:
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Type: Journal Article; Review Date: 2009-04-01 |
Journal Detail:
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Title: Hormone research Volume: 71 ISSN: 1423-0046 ISO Abbreviation: Horm. Res. Publication Date: 2009 |
Date Detail:
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Created Date: 2009-05-14 Completed Date: 2009-08-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0366126 Medline TA: Horm Res Country: Switzerland |
Other Details:
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Languages: eng Pagination: 253-9 Citation Subset: IM |
Copyright Information:
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Copyright 2009 S. Karger AG, Basel. |
Affiliation:
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Endocrinology Unit, Department of Pediatrics, Pontificia Universidad Católica de Chile, Santiago, Chile. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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11-beta-Hydroxysteroid Dehydrogenase Type 2
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genetics 11-beta-Hydroxysteroid Dehydrogenases / deficiency, genetics Adrenal Hyperplasia, Congenital / genetics Angiotensinogen / genetics Drug Resistance / physiology Epithelial Sodium Channel / genetics Glucocorticoids / physiology Humans Hyperaldosteronism / genetics Hypertension / genetics* Mineralocorticoid Excess Syndrome, Apparent / physiopathology Peptidyl-Dipeptidase A / genetics Phenotype Receptor, Angiotensin, Type 1 / genetics Receptors, Mineralocorticoid / genetics Syndrome |
| Chemical | |
Reg. No./Substance:
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0/Epithelial Sodium Channel; 0/Glucocorticoids; 0/Receptor, Angiotensin, Type 1; 0/Receptors, Mineralocorticoid; 0/SCNN1B protein, human; 11002-13-4/Angiotensinogen; EC 1.1.1.146/11-beta-Hydroxysteroid Dehydrogenase Type 2; EC 1.1.1.146/11-beta-Hydroxysteroid Dehydrogenases; EC 3.4.15.1/Peptidyl-Dipeptidase A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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