Document Detail


Genetics of hypertensive syndrome.
MedLine Citation:
PMID:  19339789     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The knowledge of the genetic bases of hypertension has improved over the last decade; this area of research has high priority due to the high incidence of hypertension and its impact on public health. Monogenetic mineralocorticoid hypertension syndromes are associated with suppressed plasma renin activity due to excessive activation of the mineralocorticoid pathway. We review the pathophysiology, phenotype, and method of diagnosis for familial hyperaldosteronism type I and type II, hypertensive forms of congenital adrenal hyperplasia, 11beta-hydroxysteroid dehydrogenase type 2 deficiency, Liddle's syndrome, an activating mutation of the MR, and glucocorticoid resistance. We also review some genes that could contribute to essential hypertension.
Authors:
Alejandro Martinez-Aguayo; Carlos Fardella
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Publication Detail:
Type:  Journal Article; Review     Date:  2009-04-01
Journal Detail:
Title:  Hormone research     Volume:  71     ISSN:  1423-0046     ISO Abbreviation:  Horm. Res.     Publication Date:  2009  
Date Detail:
Created Date:  2009-05-14     Completed Date:  2009-08-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0366126     Medline TA:  Horm Res     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  253-9     Citation Subset:  IM    
Copyright Information:
Copyright 2009 S. Karger AG, Basel.
Affiliation:
Endocrinology Unit, Department of Pediatrics, Pontificia Universidad Católica de Chile, Santiago, Chile.
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MeSH Terms
Descriptor/Qualifier:
11-beta-Hydroxysteroid Dehydrogenase Type 2 / genetics
11-beta-Hydroxysteroid Dehydrogenases / deficiency,  genetics
Adrenal Hyperplasia, Congenital / genetics
Angiotensinogen / genetics
Drug Resistance / physiology
Epithelial Sodium Channel / genetics
Glucocorticoids / physiology
Humans
Hyperaldosteronism / genetics
Hypertension / genetics*
Mineralocorticoid Excess Syndrome, Apparent / physiopathology
Peptidyl-Dipeptidase A / genetics
Phenotype
Receptor, Angiotensin, Type 1 / genetics
Receptors, Mineralocorticoid / genetics
Syndrome
Chemical
Reg. No./Substance:
0/Epithelial Sodium Channel; 0/Glucocorticoids; 0/Receptor, Angiotensin, Type 1; 0/Receptors, Mineralocorticoid; 0/SCNN1B protein, human; 11002-13-4/Angiotensinogen; EC 1.1.1.146/11-beta-Hydroxysteroid Dehydrogenase Type 2; EC 1.1.1.146/11-beta-Hydroxysteroid Dehydrogenases; EC 3.4.15.1/Peptidyl-Dipeptidase A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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