Document Detail


Genetics and heart disease.
MedLine Citation:
PMID:  12590266     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Production of genome sequence has recently skyrocketed with many advances in the understanding and etiology of certain diseases. Researchers have localized a region of the human genome that plays a role in determining a persons susceptibility to myocardial infarction. A new apolipoprotein gene that influences triglyceride levels in humans is also described. A recent study from Finland showed that certain families are likely to carry a genetic form of insulin resistance syndrome that predisposes them to accelerated atherosclerosis. Researchers identified 3 mutations in the gene producing a protein called metavinculin, which appears to be linked to abnormalities in cellular structures and function in patients with dilated cardiomyopathy. Gene therapy has emerged as a genuine therapeutic option with the potential to alter the manner in which cardiologists manage the 2 most common cardiac disorders--coronary artery disease and congestive heart failure. Along with angiogenesis and gene therapy, cell transplantation is one of the newest treatment modalities proposed to improve the outcome of patients with cardiac failure. Two major advances in stem cell therapy for cardiovascular disease were published recently. They demonstrate how bone marrow stem cells can regenerate myocardium in the infarct area of a mouse heart. A German Cardiologist has for the first time successfully transplanted a patients own stem cells in an infracted area in the heart. This review summarizes the current knowledge of the genetic associations with cardiac diseases.
Authors:
Hassan Chamsi Pasha
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Saudi medical journal     Volume:  24     ISSN:  0379-5284     ISO Abbreviation:  Saudi Med J     Publication Date:  2003 Jan 
Date Detail:
Created Date:  2003-02-18     Completed Date:  2004-09-17     Revised Date:  2008-06-23    
Medline Journal Info:
Nlm Unique ID:  7909441     Medline TA:  Saudi Med J     Country:  Saudi Arabia    
Other Details:
Languages:  eng     Pagination:  11-8     Citation Subset:  IM    
Affiliation:
Department of Cardiology, King Fahd Armed Forces Hospital, Jeddah, Kingdom of Saudi Arabia. drhcpasha@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Cardiomyopathies / genetics,  therapy
Coronary Artery Disease / genetics
Gene Therapy
Genetic Markers
Genetic Predisposition to Disease
Heart Diseases / genetics*,  therapy
Humans
Myoblasts, Skeletal / transplantation
Myocardial Infarction / genetics
Pharmacogenetics
Stem Cell Transplantation
Chemical
Reg. No./Substance:
0/Genetic Markers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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