Document Detail


Genetics and genomics of core short tandem repeat loci used in human identity testing.
MedLine Citation:
PMID:  16566758     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Over the past decade, the human identity testing community has settled on a set of core short tandem repeat (STR) loci that are widely used for DNA typing applications. A variety of commercial kits enable robust amplification of these core STR loci. A brief history is presented regarding the selection of core autosomal and Y-chromosomal STR markers. The physical location of each STR locus in the human genome is delineated and allele ranges and variants observed in human populations are summarized as are mutation rates observed from parentage testing. Internet resources for additional information on core STR loci are reviewed. Additional topics are also discussed, including potential linkage of STR loci to genetic disease-causing genes, probabilistic predictions of sample ethnicity, and desirable characteristics for additional STR loci that may be added in the future to the current core loci. These core STR loci, which form the basis for DNA databases worldwide, will continue to play an important role in forensic science for many years to come.
Authors:
John M Butler
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Journal of forensic sciences     Volume:  51     ISSN:  0022-1198     ISO Abbreviation:  J. Forensic Sci.     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-03-28     Completed Date:  2006-05-04     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0375370     Medline TA:  J Forensic Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  253-65     Citation Subset:  IM    
Affiliation:
National Institute of Standards and Technology, Gaithersburg, MD 20899-8311, USA. john.butler@nist.gov
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MeSH Terms
Descriptor/Qualifier:
Alleles
Chromosomes, Human, Y
DNA Fingerprinting*
Databases as Topic
Ethnic Groups / genetics
Genetic Markers
Genetic Variation
Genetics, Population
Genomics
Humans
Mutation
Tandem Repeat Sequences*
Chemical
Reg. No./Substance:
0/Genetic Markers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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