Document Detail


Genetics and gene-environment interactions in atopic diseases. The Norwegian Mother and Child Cohort Study.
MedLine Citation:
PMID:  18073489     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: The Norwegian Mother and Child Cohort Study (MoBa) aims to provide new insights in a broad variety of diseases. The goal of the study is to understand pathways in disease development, and identify preventive measures. Several designs are suitable for studying genetics in complex diseases like asthma and allergy, in MoBa. METHODS: MoBa is a prospective population based cohort of 100 000 pregnancies, following offspring into adulthood. Enrollment started in 1999, and will be completed in 2008. A biobank with samples from the mother, father and child, together with detailed questionnaires from early pregnancy and childhood constitute the basis of the study. When studying complex diseases like asthma, a design with case-parent triads is useful. Parental effects and interactions between maternal and fetal genes can be detected. Stratifying triads by environmental exposure enables assessment of gene-environment interactions. RESULTS: By July 2006, more than 73,000 pregnancies have been included, with nearly 7,000 siblings and 1,300 pairs of twins enrolled. Biological samples are processed and stored at the biobank. The first children are reaching age seven in 2006. CONCLUSION: The MoBa cohort provides an excellent basis for studying genetic, epigenetic and environmental influences on complex diseases.
Authors:
Siri E Håberg; Per Nafstad; Wenche Nystad; Per Magnus
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Publication Detail:
Type:  Journal Article     Date:  2007-12-11
Journal Detail:
Title:  Human heredity     Volume:  65     ISSN:  1423-0062     ISO Abbreviation:  Hum. Hered.     Publication Date:  2008  
Date Detail:
Created Date:  2008-01-30     Completed Date:  2008-02-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0200525     Medline TA:  Hum Hered     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  195-8     Citation Subset:  IM    
Copyright Information:
(c) 2007 S. Karger AG, Basel
Affiliation:
Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway. siri.haberg@fhi.no
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MeSH Terms
Descriptor/Qualifier:
Child
Child, Preschool
Cohort Studies
Environmental Exposure*
Fathers
Female
Genetic Predisposition to Disease*
Humans
Hypersensitivity / epidemiology*,  etiology*
Infant
Male
Mothers
Norway / epidemiology
Pregnancy
Questionnaires
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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