Document Detail


Genetics of food allergy.
MedLine Citation:
PMID:  19851108     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE OF REVIEW: Food allergy, a growing clinical and public health problem in the United States and worldwide, is likely determined by multiple environmental and genetic factors. The purpose of this review is to summarize recent advances in food allergy genetic research.
RECENT FINDINGS: There is compelling evidence that genetic factors may play a role in food allergy. However, the specific genetic loci that may modulate individual risk of food allergy remain to be identified. To date, only a limited number of candidate gene association studies of food allergy have been reported. Polymorphism(s) in nine genes have been associated with the incidence of food allergy or food allergy severity in at least one study. But most of these findings remain to be replicated in independent populations. In contrast, there are considerable advances in genetics of other allergic diseases such as asthma and atopic dermatitis. Although asthma and atopic dermatitis often coexist with food allergy, the relevance of their candidate genes to food allergy remains to be evaluated.
SUMMARY: Genetics in food allergy is a promising research area but is still in its infancy. More studies are needed to dissect susceptible genes of food allergy. A genome-wide association approach may serve as a powerful tool to identify novel genes related to food allergy. Furthermore, the role of gene-environment interaction, gene-gene interaction, and epigenetics in food allergy remains largely unexplored. Given the complex nature of food allergy, future studies need to integrate environment, genomics, and epigenomics in order to better understand the multifaceted etiology and biological mechanisms of food allergy.
Authors:
Xiumei Hong; Hui-Ju Tsai; Xiaobin Wang
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current opinion in pediatrics     Volume:  21     ISSN:  1531-698X     ISO Abbreviation:  Curr. Opin. Pediatr.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-11-20     Completed Date:  2010-02-17     Revised Date:  2014-09-15    
Medline Journal Info:
Nlm Unique ID:  9000850     Medline TA:  Curr Opin Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  770-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Child
Food Hypersensitivity / diagnosis,  genetics*
Genetic Predisposition to Disease / genetics*
Humans
Polymorphism, Single Nucleotide
Grant Support
ID/Acronym/Agency:
R01 HD041702/HD/NICHD NIH HHS; R21 AI079872/AI/NIAID NIH HHS; R21 AI079872-02/AI/NIAID NIH HHS; R21AI079872/AI/NIAID NIH HHS; R56 AI080627/AI/NIAID NIH HHS; R56 AI080627-01/AI/NIAID NIH HHS; R56AI080627/AI/NIAID NIH HHS
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