Document Detail

Genetics of familial combined hyperlipidemia.
MedLine Citation:
PMID:  11122695     Owner:  NLM     Status:  MEDLINE    
Complex disorders are caused by several environmental factors that interact with multiple genes. These diseases are common at the population level and constitute a major health problem in Western societies. Familial combined hyperlipidemia (FCHL) is characterized by elevated levels of serum total cholesterol, triglycerides, or both. This disorder is estimated to be common in Western populations with a prevalence of 1% to 2%. In addition, 14% of patients with premature coronary heart disease (CHD) have FCHL, making this disorder one of the most common genetic dyslipidemias underlying premature CHD. Both genetic and environmental factors are suggested to affect the complex FCHL phenotype, but no specific susceptibility genes to FCHL have been identified. It is hoped that further analysis of the first FCHL locus and other new loci obtained in genome-wide scans will guide us to genes predisposing to this complex disorder.
P Pajukanta; K V Porkka
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current atherosclerosis reports     Volume:  1     ISSN:  1523-3804     ISO Abbreviation:  Curr Atheroscler Rep     Publication Date:  1999 Jul 
Date Detail:
Created Date:  2001-01-26     Completed Date:  2001-07-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  100897685     Medline TA:  Curr Atheroscler Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  79-86     Citation Subset:  IM    
University of California, Los Angeles, Department of Human Genetics, Los Angeles, California, USA.
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MeSH Terms
Apolipoprotein A-I / genetics
Chromosome Mapping
Coronary Disease / etiology,  genetics
Genetic Predisposition to Disease
Hyperlipidemia, Familial Combined / complications,  genetics*
Linkage (Genetics)
Lipoprotein Lipase / genetics
Reg. No./Substance:
0/Apolipoprotein A-I; EC Lipase

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