Document Detail


Genetics and evolution of the acute phase proteins in mice.
MedLine Citation:
PMID:  3866909     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In mammals, a number of liver-derived plasma proteins, termed acute phase reactants, are induced during an inflammation response. We have studied genetic variation in the structure and expression of several of these proteins in a variety of inbred and wild-derived mice. In a genetic cross, electrophoretic polymorphisms for the two alpha 1-acid glycoproteins, AGP-1 and AGP-2, co-segregated in 58 backcross progeny, indicating that either a single gene or two tightly-linked genes on chromosome 4 encode the AGPs. In the same backcross, segregation of variation in haptoglobin structure showed that the gene encoding this acute phase reactant is on chromosome 8. Structural variation in serum amyloid A correlated with restriction fragment length polymorphisms in the Saa gene determined by Taylor and Rowe (1984). Analysis of a number of highly diverged species of mice indicated that AGP expression has undergone considerable modification during evolution of the Mus genus; this is associated with alterations in Agp gene organization, which may include species-specific amplification and/or deletion events.
Authors:
H Baumann; F G Berger
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Molecular & general genetics : MGG     Volume:  201     ISSN:  0026-8925     ISO Abbreviation:  Mol. Gen. Genet.     Publication Date:  1985  
Date Detail:
Created Date:  1986-03-21     Completed Date:  1986-03-21     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0125036     Medline TA:  Mol Gen Genet     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  505-12     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
C-Reactive Protein / genetics*
Chromosome Mapping
Evolution*
Genes
Genetic Variation
Mice
Mice, Inbred Strains
Muridae / genetics*
Orosomucoid / genetics
Species Specificity
Grant Support
ID/Acronym/Agency:
AM 33886/AM/NIADDK NIH HHS; GM 33160/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Orosomucoid; 9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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