Document Detail


Genetics of event-related brain potentials in response to a semantic priming paradigm in families with a history of alcoholism.
MedLine Citation:
PMID:  11102287     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Event-related brain potentials (ERPs) are altered in patients with a variety of psychiatric disorders and may represent quantitative correlates of disease liability that are more amenable to genetic analysis than disease status itself. Results of a genomewide linkage screen are presented for amplitude of the N4 and P3 components of the ERP, measured at 19 scalp locations in response to a semantic priming task for 604 individuals in 100 pedigrees ascertained as part of the Collaborative Study on the Genetics of Alcoholism. N4 and P3 amplitudes in response to three stimuli (nonwords, primed words [i.e., antonyms], and unprimed words) all showed significant heritabilities, the highest being.54. Both N4 and P3 showed significant genetic correlations across stimulus type at a given lead and across leads within a stimulus, indicating shared genetic influences among the traits. There were also substantial genetic correlations between the N4 and P3 amplitudes for a given lead, even across stimulus type. N4 amplitudes showed suggestive evidence of linkage in several chromosomal regions, and P3 amplitudes showed significant evidence of linkage to chromosome 5 and suggestive evidence of linkage to chromosome 4.
Authors:
L Almasy; B Porjesz; J Blangero; A Goate; H J Edenberg; D B Chorlian; S Kuperman; S J O'Connor; J Rohrbaugh; L O Bauer; T Foroud; J P Rice; T Reich; H Begleiter
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.     Date:  2000-12-01
Journal Detail:
Title:  American journal of human genetics     Volume:  68     ISSN:  0002-9297     ISO Abbreviation:  Am. J. Hum. Genet.     Publication Date:  2001 Jan 
Date Detail:
Created Date:  2001-01-26     Completed Date:  2001-02-15     Revised Date:  2013-08-14    
Medline Journal Info:
Nlm Unique ID:  0370475     Medline TA:  Am J Hum Genet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  128-135     Citation Subset:  IM    
Affiliation:
Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX, 78245, USA. almasy@darwin.sfbr.org
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MeSH Terms
Descriptor/Qualifier:
Alcoholism / etiology,  genetics*,  physiopathology*
Chromosome Mapping
Chromosomes, Human / genetics
Environment
Evoked Potentials / physiology*
Female
Genetic Testing
Genotype
Humans
Likelihood Functions
Lod Score
Male
Microsatellite Repeats / genetics
Pedigree
Phenotype
Polymorphism, Genetic / genetics
Quantitative Trait, Heritable*
Grant Support
ID/Acronym/Agency:
MH59490/MH/NIMH NIH HHS; U10 AA008401/AA/NIAAA NIH HHS; U10AA08403/AA/NIAAA NIH HHS
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