Document Detail

Genetics and developmental pathology of twinning.
MedLine Citation:
PMID:  20663725     Owner:  NLM     Status:  MEDLINE    
Twin pregnancy is associated with a high risk of congenital malformations. This review covers the risk of such anomalies in both dizygotic and monozygotic twin pregnancies, and discusses current insights into the associations relating to zygosity, chorionicity and genetic factors. The pathological basis of specific malformations unique to the monochorionic twinning process, including conjoined twinning and twin reversed arterial perfusion (TRAP) sequence, is discussed in more detail, and factors contributing to the higher perinatal mortality rate in multiple pregnancies are addressed.
Martin A Weber; Neil J Sebire
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Seminars in fetal & neonatal medicine     Volume:  15     ISSN:  1878-0946     ISO Abbreviation:  Semin Fetal Neonatal Med     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-10-18     Completed Date:  2011-02-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101240003     Medline TA:  Semin Fetal Neonatal Med     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  313-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ltd. All rights reserved.
Department of Paediatric Pathology, Great Ormond Street Hospital for Children, London, UK.
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MeSH Terms
Chromosome Aberrations
Congenital Abnormalities / embryology,  genetics,  mortality,  physiopathology*
Diseases in Twins / embryology,  genetics,  mortality,  physiopathology*
Heart Defects, Congenital / embryology,  physiopathology
Perinatal Mortality
Twins, Conjoined / embryology,  physiopathology
Twins, Dizygotic
Twins, Monozygotic

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