Document Detail

Genetics of coronary artery disease and myocardial infarction - 2013.
MedLine Citation:
PMID:  23616109     Owner:  NLM     Status:  In-Data-Review    
Coronary artery disease is a complex disease influenced by modifiable risk factors as well as genetic susceptibility. The genetics of coronary artery disease and myocardial infarction have long been enigmatic. Recent advances in molecular genetics and biology, bioinformatics, and statistics have allowed us to study the interaction of exogenous and endogenous factors. Recent genome-wide association studies and their meta-analyses have included thousands of patients and healthy individuals and provided the statistical power to identify genetic variants, each associated with a rather small increase in risk. Thus far, more than 45 risk loci have been identified. Nevertheless, the search for genetics-based improvements in therapy and prevention has just begun. Hitherto unrecognized mechanisms may provide promising drug targets and early interventional strategies. Furthermore, the sum of risk alleles may facilitate risk assessment as they provide complementary information to traditional risk scores.
Thorsten Kessler; Jeanette Erdmann; Heribert Schunkert
Related Documents :
17781759 - Mutations: incidence in drosophila melanogaster reared on irradiated medium.
11204979 - Estimation of microsatellite mutation rates in drosophila melanogaster.
6430569 - A molecular analysis of fushi tarazu, a gene in drosophila melanogaster that encodes a ...
2500289 - Molecular genetics of delta, a locus required for ectodermal differentiation in drosoph...
7737139 - Induction of delayed mutations by benzene and ethylene dibromide in drosophila.
24634229 - Association study of c.910a>g and c.1686c>g polymorphisms in xrcc1 gene with risk of he...
19229559 - Sca8 repeat expansion: large cta/ctg repeat alleles in neurological disorders and funct...
22697369 - Development and evaluation of 200 novel snp assays for population genetic studies of we...
23622369 - Congenital myasthenic syndromes.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Current cardiology reports     Volume:  15     ISSN:  1534-3170     ISO Abbreviation:  Curr Cardiol Rep     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-04-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888969     Medline TA:  Curr Cardiol Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  368     Citation Subset:  IM    
Klinik für Herz- und Kreislauferkrankungen, Deutsches Herzzentrum München, Technische Universität München, Lazarettstraße 36, 80636, München, Germany,
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Relative contributions of the thalamus and the paraventricular nucleus of the hypothalamus to the ca...
Next Document:  Menopausal symptoms, sexual function, depression, and quality of life in Korean patients with breast...