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Genetics of coagulation: what the cardiologist needs to know.
MedLine Citation:
PMID:  23261321     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Hemostasis maintains the blood in a fluid state under physiological conditions, yet enables rapid clot formation at sites of vascular injury to prevent excessive bleeding. Disruption of hemostasis can lead to thrombosis, which can occur in arteries, veins, or in the chambers of the heart. Factors contributing to thrombosis in these sites include endothelial injury, reduced blood flow, and hypercoagulability of the blood. Vessel wall injury and stasis are particularly important in the pathogenesis of arterial thrombosis, whereas hypercoagulability and stasis are the key contributors to venous thrombosis. Hereditary and acquired risk factors combine to establish the intrinsic risk for thrombosis in each individual and superimposed environmental factors can add to this risk. Although hereditable risk factors for venous thrombosis are well defined, much less is known about the genetic risk factors for arterial thrombosis. This article reviews our current knowledge of hereditable risk factors for arterial and venous thrombosis from the cardiology perspective.
Authors:
Julia A Anderson; Wendy Lim; Jeffrey I Weitz
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Canadian journal of cardiology     Volume:  29     ISSN:  1916-7075     ISO Abbreviation:  Can J Cardiol     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8510280     Medline TA:  Can J Cardiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  75-88     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights reserved.
Affiliation:
Department of Clinical and Laboratory Hematology, Royal Infirmary of Edinburgh, Edinburgh, Scotland; Thrombosis and Atherosclerosis Research Institute, Hamilton, Ontario, Canada.
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