| Genetics of the cervix in relation to preterm birth. | |
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MedLine Citation:
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PMID: 19796727 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Preterm birth is the most significant problem encountered in obstetrics in the developed world. Genetic factors are thought to play a role in a proportion of preterm births, and candidate genes have been studied in several areas relevant to parturition. Abnormal cervical function, a clinical spectrum, including cervical insufficiency (CI), is a contributing factor to the overall problem of preterm birth. There are many risk factors and etiologies for CI. However, it is becoming clear that, at least in part, a genetic predisposition to CI plays a role in the condition. Specifically, genes related to connective tissue metabolism and inflammation have been shown to be associated with CI. |
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Authors:
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Jennifer E Warren; Robert M Silver |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Seminars in perinatology Volume: 33 ISSN: 1558-075X ISO Abbreviation: Semin. Perinatol. Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-10-02 Completed Date: 2010-02-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7801132 Medline TA: Semin Perinatol Country: United States |
Other Details:
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Languages: eng Pagination: 308-11 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, UT 84132, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cervix Uteri
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physiology* Connective Tissue / immunology, metabolism* Female Genetic Predisposition to Disease Humans Infant, Newborn Pregnancy Premature Birth / genetics* Uterine Cervical Incompetence / genetics*, immunology, metabolism |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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