Document Detail


Genetics of adrenal tumors.
MedLine Citation:
PMID:  19471236     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The impact of genetics and genomics on clinical medicine is becoming more and more important. Endocrinology pioneered the development of molecular medicine, but also the study of adrenal tumors had a great impact in this field. Particularly important was the detection of genetics of tumors derived from the adrenal medulla, as well as that of those derived from the sympathetic and parasympathetic paraganglia. The identification of mutations in one of the several pheochromocytoma/paraganglioma susceptibility genes may indicate a specific clinical management drive. Less well understood is the genetics of adrenal cortex tumors, in particular adrenocortical carcinoma, a rare and particularly aggressive disease. There are only a few examples of hereditary transmission of adrenocortical carcinoma, but the analysis of low penetrance genes by genome wide association study may enable us to discover new genetic mechanisms responsible for adrenocortical-derived tumors.
Authors:
G Opocher; F Schiavi; M V Cicala; A Patalano; B Mariniello; F Boaretto; S Zovato; V Pignataro; B Macino; I Negro; F Mantero
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Minerva endocrinologica     Volume:  34     ISSN:  0391-1977     ISO Abbreviation:  Minerva Endocrinol.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-27     Completed Date:  2009-10-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8406505     Medline TA:  Minerva Endocrinol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  107-21     Citation Subset:  IM    
Affiliation:
Familial Cancer Clinic, Veneto Institute of Oncology, Padua, Italy. giuseppe.opocher@ioveneto.it
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MeSH Terms
Descriptor/Qualifier:
Adrenal Cortex Neoplasms / genetics
Adrenal Gland Neoplasms / genetics*,  pathology
Adrenocortical Carcinoma / genetics
Genetic Predisposition to Disease
Genomics
Humans
Mutation*
Neoplasm Proteins / genetics
Paraganglioma / genetics
Pheochromocytoma / genetics*,  pathology
Tumor Markers, Biological / genetics*
Chemical
Reg. No./Substance:
0/Neoplasm Proteins; 0/Tumor Markers, Biological

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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