Document Detail


Genetics of salt-sensitive hypertension.
MedLine Citation:
PMID:  21058046     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The assessment of salt sensitivity of blood pressure is difficult because of the lack of universal consensus on definition. Regardless of the variability in the definition of salt sensitivity, increased salt intake, independent of the actual level of blood pressure, is also a risk factor for cardiovascular morbidity and mortality and kidney disease. A modest reduction in salt intake results in an immediate decrease in blood pressure, with long-term beneficial consequences. However, some have suggested that dietary sodium restriction may not be beneficial to everyone. Thus, there is a need to distinguish salt-sensitive from salt-resistant individuals, but it has been difficult to do so with phenotypic studies. Therefore, there is a need to determine the genes that are involved in salt sensitivity. This review focuses on genes associated with salt sensitivity, with emphasis on the variants associated with salt sensitivity in humans that are not due to monogenic causes. Special emphasis is given to gene variants associated with salt sensitivity whose protein products interfere with cell function and increase blood pressure in transgenic mice.
Authors:
Hironobu Sanada; John E Jones; Pedro A Jose
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Current hypertension reports     Volume:  13     ISSN:  1534-3111     ISO Abbreviation:  Curr. Hypertens. Rep.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-04     Completed Date:  2011-05-04     Revised Date:  2014-05-21    
Medline Journal Info:
Nlm Unique ID:  100888982     Medline TA:  Curr Hypertens Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  55-66     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Blood Pressure / drug effects,  genetics
Cardiovascular Diseases / embryology,  genetics,  pathology
Gene Expression
Humans
Hypertension / chemically induced,  epidemiology,  genetics*
Kidney Diseases / epidemiology
Nitric Oxide Synthase / drug effects,  genetics
Renin-Angiotensin System / drug effects*
Risk Factors
Sodium, Dietary / administration & dosage*,  metabolism
Sympathetic Nervous System / drug effects
United States / epidemiology
Grant Support
ID/Acronym/Agency:
R01 HL092196/HL/NHLBI NIH HHS; R02HL092196/HL/NHLBI NIH HHS; R37 HL023081/HL/NHLBI NIH HHS; R37HL02308/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Sodium, Dietary; EC 1.14.13.39/Nitric Oxide Synthase
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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