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Genetics and Personalized Medicine-a Role in Statin Therapy?
MedLine Citation:
PMID:  24293347     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Pharmacogenetics uses the genetic variation in metabolic pathways to identify groups of patients who may respond differently in terms of therapeutic and adverse effects. Much clinical interest lies in drug metabolism and the opportunity to improve prescribing efficacy and safety. Owing to widespread use and increasing concern regarding side effects, statins are of significant interest in this area. Among other benefits, statins have been shown to improve lipid profiles and reduce coronary heart disease event rates in many populations. However, variability in drug response exists, and genetic variability may be a contributing factor. Our primary goal is to feature the most important genes involved in lipid metabolism, clinical outcomes, and statin-induced side effects, highlighting genome-wide association studies and the candidate gene approach.
Authors:
Jaideep Patel; Thura Abd; Roger S Blumenthal; Khurram Nasir; H Robert Superko
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Current atherosclerosis reports     Volume:  16     ISSN:  1534-6242     ISO Abbreviation:  Curr Atheroscler Rep     Publication Date:  2014 Jan 
Date Detail:
Created Date:  2013-12-02     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100897685     Medline TA:  Curr Atheroscler Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  384     Citation Subset:  IM    
Affiliation:
Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD, USA.
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