| Genetics of NIDDM. | |
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MedLine Citation:
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PMID: 1979769 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This brief review discusses the current level of understanding of the role of genetic defects in the etiology of non-insulin-dependent diabetes mellitus (NIDDM) and the use of molecular-genetic methods for this study. Evidence for genetic susceptibility is strong, and defects in both insulin production and action are suspect. With restriction-fragment-length polymorphisms and genomic sequencing, various candidate loci are being evaluated. Evidence that multiple genes are involved is only circumstantial. If NIDDM is genetically heterogeneous and also influenced by environmental components, population associations and linkage analyses in families may not be as easily interpreted as for diseases involving single major gene defects. |
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Authors:
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M A Permutt |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Diabetes care Volume: 13 ISSN: 0149-5992 ISO Abbreviation: Diabetes Care Publication Date: 1990 Nov |
Date Detail:
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Created Date: 1991-02-04 Completed Date: 1991-02-04 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 7805975 Medline TA: Diabetes Care Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1150-3 Citation Subset: IM |
Affiliation:
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Metabolism Division, Washington University School of Medicine, St. Louis, Missouri 63110. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Diabetes Mellitus, Type 2
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genetics* Disease Susceptibility Humans Insulin / genetics Monosaccharide Transport Proteins / genetics Polymorphism, Restriction Fragment Length |
| Chemical | |
Reg. No./Substance:
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0/Monosaccharide Transport Proteins; 11061-68-0/Insulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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