Document Detail

The genetics of congestive heart failure.
MedLine Citation:
PMID:  20347790     Owner:  NLM     Status:  MEDLINE    
The heart failure syndrome is known to represent a final common pathway for a broad range of etiologies, but there is tremendous variation in the propensity to develop congestive heart failure after a given insult. This variation is thought to result in part from inherited differences in myocardial, vascular or systemic responses, but the nature of the underlying traits responsible ultimately for the development of heart failure has remained elusive. There has been limited progress in the genetic exploration of the key clinical phenotype itself: heart failure. In this article, the author attempts to place the results of genetic studies of cardiomyopathy in the broader context of the clinical syndrome of heart failure, highlighting some of the key questions for future study.
Calum A MacRae
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Heart failure clinics     Volume:  6     ISSN:  1551-7136     ISO Abbreviation:  Heart Fail Clin     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-29     Completed Date:  2010-07-23     Revised Date:  2014-06-30    
Medline Journal Info:
Nlm Unique ID:  101231934     Medline TA:  Heart Fail Clin     Country:  United States    
Other Details:
Languages:  eng     Pagination:  223-30     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 Elsevier Inc. All rights reserved.
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MeSH Terms
Cardiomyopathies / genetics
Genome-Wide Association Study
Heart Failure / diagnosis,  etiology,  genetics*
Risk Factors
Grant Support
R01 HL075431-04/HL/NHLBI NIH HHS; R01 HL109264/HL/NHLBI NIH HHS; R21 HL098938-01/HL/NHLBI NIH HHS

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