Document Detail


The genetics of conduction disease.
MedLine Citation:
PMID:  20347788     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Conduction diseases (CD) include defects in impulse generation and conduction. Patients with CD may manifest a wide range of clinical presentations, from asymptomatic to potentially life-threatening arrhythmias. The pathophysiologic mechanisms underlying CD are diverse and may have implications for diagnosis, treatment, and prognosis. Known causes of functional CD include cardiac ion channelopathies or defects in modifying proteins, such as cytoskeletal proteins. Progress in molecular biology and genetics along with development of animal models has increased the understanding of the molecular mechanisms of these disorders. This article discusses the genetic basis for CD and its clinical implications.
Authors:
Roy Beinart; Jeremy Ruskin; David Milan
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Heart failure clinics     Volume:  6     ISSN:  1551-7136     ISO Abbreviation:  Heart Fail Clin     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-29     Completed Date:  2010-07-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101231934     Medline TA:  Heart Fail Clin     Country:  United States    
Other Details:
Languages:  eng     Pagination:  201-14     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 Elsevier Inc. All rights reserved.
Affiliation:
Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.
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MeSH Terms
Descriptor/Qualifier:
Arrhythmias, Cardiac / diagnosis,  genetics*,  physiopathology
Channelopathies / genetics
Connexins
Cytoskeletal Proteins / metabolism
Fatty Acids / metabolism
Heart Conduction System / physiopathology*
Heart Septal Defects / pathology
Humans
Prognosis
Protein Kinases
Risk Factors
Chemical
Reg. No./Substance:
0/Connexins; 0/Cytoskeletal Proteins; 0/Fatty Acids; EC 2.7.-/Protein Kinases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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