Document Detail

Genetically related rats with differences in hippocampal uptake of norepinephrine and maze performance.
MedLine Citation:
PMID:  6478258     Owner:  NLM     Status:  MEDLINE    
The spontaneously hypertensive rat (SHR) and its progenitor strain, the Wistar-Kyoto (WKY) display marked differences in brain catecholamines and behavior. The behavioral differences are suggestive of alterations in hippocampal function and, in particular, the noradrenergic input to the hippocampus. To test these hypotheses we have analyzed the performance of the SHR and WKY in a spatial memory maze task that is specific to hippocampal function and determined the kinetics of norepinephrine (NE) uptake in synaptosomal preparations of the hippocampus. We have found that WKYs exhibit an abnormally strong bias tendency in T-maze arm preference that influences the rate of acquisition and the final level of maze performance. We have also found differences in noradrenergic uptake in hippocampal synaptosomes. WKYs exhibit higher NE uptake rates and higher kinetic constants for NE uptake when compared with SHRs, suggesting that strain differences in noradrenergic function may contribute to the observed behavioral differences.
W C Low; D Whitehorn; E D Hendley
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Brain research bulletin     Volume:  12     ISSN:  0361-9230     ISO Abbreviation:  Brain Res. Bull.     Publication Date:  1984 Jun 
Date Detail:
Created Date:  1984-11-19     Completed Date:  1984-11-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7605818     Medline TA:  Brain Res Bull     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  703-9     Citation Subset:  IM    
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MeSH Terms
Biological Transport
Conditioning (Psychology)*
Hippocampus / metabolism*
Norepinephrine / metabolism*
Rats, Inbred SHR / physiology*
Rats, Inbred Strains / physiology*
Rats, Inbred WKY / physiology*
Species Specificity
Grant Support
Reg. No./Substance:

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