| Genetically modified cells in regenerative medicine and tissue engineering. | |
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MedLine Citation:
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PMID: 20114067 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Regenerative medicine appears to take as its patron, the Titan Prometheus, whose liver was able to regenerate daily, as the field attempts to restore lost, damaged, or aging cells and tissues. The tremendous technological progress achieved during the last decade in gene transfer methods and imaging techniques, as well as recent increases in our knowledge of cell biology, have opened new horizons in the field of regenerative medicine. Genetically engineered cells are a tool for tissue engineering and regenerative medicine, albeit a tool whose development is fraught with difficulties. Gene-and-cell therapy offers solutions to severe problems faced by modern medicine, but several impediments obstruct the path of such treatments as they move from the laboratory toward the clinical setting. In this review we provide an overview of recent advances in the gene-and-cell therapy approach and discuss the main hurdles and bottlenecks of this approach on its path to clinical trials and prospective clinical practice. |
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Authors:
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Dima Sheyn; Olga Mizrahi; Shimon Benjamin; Zulma Gazit; Gadi Pelled; Dan Gazit |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review Date: 2010-01-28 |
Journal Detail:
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Title: Advanced drug delivery reviews Volume: 62 ISSN: 1872-8294 ISO Abbreviation: Adv. Drug Deliv. Rev. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-14 Completed Date: 2010-09-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8710523 Medline TA: Adv Drug Deliv Rev Country: Netherlands |
Other Details:
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Languages: eng Pagination: 683-98 Citation Subset: IM |
Copyright Information:
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2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Hebrew University of Jerusalem, Israel. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Transplantation / methods Clinical Trials as Topic Gene Therapy / methods Genetic Engineering / methods* Humans Regenerative Medicine / methods* Stem Cell Transplantation / methods Tissue Engineering / methods* |
| Grant Support | |
ID/Acronym/Agency:
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R01 AR056694/AR/NIAMS NIH HHS; R03 AR057143/AR/NIAMS NIH HHS; R43 AR057587/AR/NIAMS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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