Document Detail


Genetically engineered mice: a new paradigm to study gastric physiology.
MedLine Citation:
PMID:  17906435     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE OF REVIEW: To summarize key aspects from recent research as well as review articles on the topic of genetic mouse models, particularly in knockout mice, that have considerably contributed to understanding the pathways and mechanisms underlying gastric physiology. RECENT FINDINGS: A series of knockout mouse models has proven to be invaluable in elucidating the mechanism and validating the current model of acid secretion. The interaction between the gastrin-histamine and cholecystokinin-somatostatin pathways was identified using the genetic approach as being critical in regulating acid secretion. Curiously, neither ghrelin nor ghrelin receptor knockout mice displayed the expected lean phenotype. Importantly, the study of obestatin in GPR39 knockout mice could be misleading, as zinc rather than obestatin is the endogenous ligand for GPR39. The physiological roles of ghrelin and obestatin have yet to be confirmed using knockout mouse models. SUMMARY: The knockout mouse continues to serve as an excellent model to dissect the complexity of the mechanism of gastric acid secretion and to study the physiological importance of gastric ghrelin.
Authors:
Duan Chen; Chun-Mei Zhao
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in gastroenterology     Volume:  23     ISSN:  0267-1379     ISO Abbreviation:  Curr. Opin. Gastroenterol.     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-10-01     Completed Date:  2008-01-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8506887     Medline TA:  Curr Opin Gastroenterol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  602-6     Citation Subset:  IM    
Affiliation:
Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway. duan.chen@ntnu.no
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MeSH Terms
Descriptor/Qualifier:
Animals
Gastric Acid / secretion
Ghrelin / physiology
Mice
Mice, Knockout
Models, Animal*
Parietal Cells, Gastric / physiology
Stomach / physiology*
Chemical
Reg. No./Substance:
0/Ghrelin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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