Document Detail

Genetically altered brain amino acid metabolism in spontaneously hypertensive rats: a study by using young spontaneously hypertensive rats and renal hypertensive rats.
MedLine Citation:
PMID:  2257687     Owner:  NLM     Status:  MEDLINE    
Previously we demonstrated altered amino acid levels in brainstem regions of adult spontaneously hypertensive rats (SHR). For comparison, in this study, we determined amino acid concentrations in discrete brainstem regions in young prehypertensive SHR and renal hypertensive rats. In prehypertensive SHR, the content of glutamate was increased in the rostral ventrolateral medulla and the caudal ventrolateral medulla, and the content of beta-alanine was decreased in the nucleus tractus solitarii. In renal hypertensive rats, there was no change in glutamate and beta-alanine contents in all the regions. The profiles of contents of glutamate and beta-alanine in the brainstem regions in young SHR but not in renal hypertensive rats are the same as those found previously in adult SHR. Thus, the results of the present study suggest that the altered amino acid metabolism in the brainstem of SHR may be genetically inherent.
T Kubo; M Kihara; Y Misu
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and experimental hypertension. Part A, Theory and practice     Volume:  12     ISSN:  0730-0077     ISO Abbreviation:  Clin Exp Hypertens A     Publication Date:  1990  
Date Detail:
Created Date:  1991-01-31     Completed Date:  1991-01-31     Revised Date:  2008-02-12    
Medline Journal Info:
Nlm Unique ID:  8207790     Medline TA:  Clin Exp Hypertens A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1191-201     Citation Subset:  IM    
Department of Pharmacology, Yokohama City University School of Medicine, Japan.
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MeSH Terms
Amino Acids / metabolism*
Brain / metabolism*
Hypertension / metabolism
Hypertension, Renal / metabolism*
Osmolar Concentration
Rats, Inbred SHR
Rats, Inbred WKY
Tissue Distribution
Reg. No./Substance:
0/Amino Acids

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