Document Detail


A Genetically Encoded Norbornene Amino Acid for the Mild and Selective Modification of Proteins in a Copper-Free Click Reaction.
MedLine Citation:
PMID:  22438179     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Built in for clicks: A specially evolved pyrrolysyl-tRNA synthetase from Methanosarcina mazei was used to incorporate a norbornene amino acid into proteins in E. coli. This unit can be site-selectively modified under mild physiological conditions using a [3+2] cycloaddition reaction with nitrile imines.
Authors:
Emine Kaya; Milan Vrabel; Christian Deiml; Stefan Prill; Viviana S Fluxa; Thomas Carell
Related Documents :
3943079 - Inhibitory effect of chlorogenic acid on methylazoxymethanol acetate-induced carcinogen...
11518429 - Contribution of starter culture to the sensory characteristics of fermented almagro egg...
23513729 - Determination of organic acids in salicornia herbacea by solid-phase extraction combine...
16657299 - Effect of oxygen on the light-enhanced dark carbon dioxide fixation in chlorella cells.
10486129 - Closed-loop control of bacterial high-cell-density fed-batch cultures: production of mc...
11434969 - Biomass production and studies on rhodopseudomonas palustris grown in an outdoor, tempe...
11166679 - Oleate, linoleate and cholesterol differently modify aspartyl- and glutamyl-aminopeptid...
17485499 - Inhibition of isolated mycobacterium tuberculosis fatty acid synthase i by pyrazinamide...
3839399 - Actions of flavonoids and the novel anti-inflammatory flavone, hypolaetin-8-glucoside, ...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-21
Journal Detail:
Title:  Angewandte Chemie (International ed. in English)     Volume:  -     ISSN:  1521-3773     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370543     Medline TA:  Angew Chem Int Ed Engl     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Affiliation:
Department Chemie, Ludwig-Maximilians-Universität, Butenandtstrasse 5-13, 81377 Munich (Germany) http://www.carellgroup.de.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Creativity and dementia: a review.
Next Document:  Smith-Lemli-Opitz syndrome: Objective assessment of facial phenotype.