Document Detail

Genetical, histological, and clinical characteristics of IgA-negative mesangioproliferative glomerulopathy.
MedLine Citation:
PMID:  19937361     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Mesangioproliferative glomerulopathy (MesPGN) is a well-defined pathohistological entity. However, the clinical characteristics and prognosis have not been fully established in patients without immunoglobulin (Ig)A (N-IgAN) in contrast to patients with IgA nephropathy (IgAN). METHODS: A total of 837 consecutive patients underwent renal biopsies. Among them, 465 patients were diagnosed with MesPGN by light microscopy. With immunofluorescent study and electron microscopy (EM), 344 were diagnosed as having IgAN. Among the rest, 84 patients who had no immunofluorescence evidence of IgA and no deposits in EM were defined as N-IgAN. We compared the clinical characteristics, histological findings, and genotypes of the angiotensin-converting enzyme (ACE) gene and plasminogen activator inhibitor-1 gene between IgAN and N-IgAN patients. RESULTS: Urinary protein excretion and the degree of hematuria were significantly lower in N-IgAN than IgAN patients (0.50 vs. 0.82 g/day; P = 0.01), (1.33 vs. 2.50; P < 0.001, respectively). Creatinine clearance was higher in N-IgAN than IgAN patients (89.4 vs. 74.4 ml/min; P < 0.001). Histopathologically, N-IgAN patients had significantly less advanced glomerular and tubulointerstitial lesions than IgAN patients. Pathological grades in patients with untreated IgAN were more advanced in a time-dependent manner, whereas there was no relationship between histological grades and time of illness in N-IgAN patients. Frequency of the DD genotype of the ACE gene was significantly lower in N-IgAN (DD/ID+II = 8/76) than IgAN (24/90) patients. CONCLUSIONS: IgA-negative MesPGN is a distinct type of glomerulopathy with a benign renal prognosis. Insertion/deletion polymorphisms of the ACE gene may play some role in the genesis and progression of MesPGN.
Kazunori Owada; Hodaka Suzuki; Tetsuo Katoh; Tsuyoshi Watanabe
Publication Detail:
Type:  Journal Article     Date:  2009-11-25
Journal Detail:
Title:  Clinical and experimental nephrology     Volume:  14     ISSN:  1437-7799     ISO Abbreviation:  Clin. Exp. Nephrol.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-26     Completed Date:  2010-05-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9709923     Medline TA:  Clin Exp Nephrol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  56-62     Citation Subset:  IM    
Department of Internal Medicine III, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, 960-1295, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Glomerulonephritis / genetics*,  pathology
Glomerulonephritis, IGA / genetics
Kidney Glomerulus / pathology
Middle Aged
Peptidyl-Dipeptidase A / genetics*
Plasminogen Activator Inhibitor 1 / genetics*
Proteinuria / genetics
Reg. No./Substance:
0/Plasminogen Activator Inhibitor 1; EC A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Good maternal and fetal outcomes of predominantly sensory Guillain-Barr?? syndrome in pregnancy afte...
Next Document:  Comparison of the effects of sibutramine versus sibutramine plus metformin in obese women.