| Genetic variations of leptin and leptin receptor are associated with body composition changes in response to physical training. | |
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MedLine Citation:
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PMID: 20517895 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Leptin regulates body weight, metabolism, and tissue adaptations to environmental stressors. We examined the association of single nucleotide polymorphism (SNP) of leptin promoter G-2548A (rs7799039) and leptin receptor Gln223Arg (rs1137101) with body composition, plasma leptin levels, and peak oxygen uptake (VO(2)peak) in response to 8 weeks of physical training in 48 male military conscripts. AA homozygotes of leptin promoter SNP-2548 showed higher body fat and BMI values than G allele carriers. Acute exercise decreased leptin levels in G allele carriers, but increased in AA homozygotes. Physical training significantly decreased BMI values and also a tendency for decreased plasma leptin levels was observed in all subjects. In G allele carriers, BMI loss was mainly due to decreased fat mass, whereas in AA homozygotes due to loss of fat-free mass. Training increased VO(2)peak in all subjects with most prominent effects in G allele carriers. Regarding leptin receptor SNP, there were no statistically significant differences in BMI values between the genotype groups at baseline or after physical training. Our results suggest that physical training-induced alterations in body composition and plasma leptin may be influenced by a genetic variation of leptin promoter but not of leptin receptor. |
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Authors:
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Antti Huuskonen; Jani Lappalainen; Minna Tanskanen; Niku Oksala; Heikki Kyröläinen; Mustafa Atalay |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cell biochemistry and function Volume: 28 ISSN: 1099-0844 ISO Abbreviation: Cell Biochem. Funct. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-02 Completed Date: 2010-09-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8305874 Medline TA: Cell Biochem Funct Country: England |
Other Details:
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Languages: eng Pagination: 306-12 Citation Subset: IM |
Copyright Information:
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2010 John Wiley & Sons, Ltd. |
Affiliation:
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Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alleles Body Composition / genetics* Body Mass Index Exercise* Genotype Homozygote Humans Leptin / blood, genetics* Male Oxygen Consumption Polymorphism, Single Nucleotide* Promoter Regions, Genetic Receptors, Leptin / blood, genetics* Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Leptin; 0/Receptors, Leptin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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