Document Detail


Genetic variation in the sodium-dependent vitamin C transporters, SLC23A1, and SLC23A2 and risk for preterm delivery.
MedLine Citation:
PMID:  16357110     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Vitamin C has been the focus of epidemiologic investigation in preterm delivery (<37 weeks' gestation), which is a leading cause of neonatal mortality and birth-related morbidity. There are two sodium-dependent membrane transporters encoded by SLC23A1 and SLC23A2, which have key roles in human vitamin C metabolism and which control dietary uptake, reabsorption, and tissue distribution of vitamin C. Using maternal DNA, the authors evaluated common single-nucleotide polymorphisms (SNPs) in SLC23A1 and SLC23A2 in a nested case-control analysis of the Pregnancy, Infection, and Nutrition Study (1995-2000) cohort. Of the associations observed for both haplotypes in SLC23A1 and individual SNPs in SLC23A2, the most robust finding is with an intron 2 variant in SLC23A2. Heterozygotes and homozygotes for this variant had a 1.7-fold (95% confidence interval: 0.9, 3.3) and a 2.7-fold (95% confidence interval: 1.2, 6.3) elevation in the risk of spontaneous preterm birth, respectively. Semi-Bayesian hierarchical regression analysis, which simultaneously adjusted for multiple SNPs within the same gene, gave comparable results. The authors' findings link genetic variants in the vitamin C transporters to spontaneous preterm birth, which may explain previous dietary associations. If the findings from this study are confirmed, they may serve as the foundation for genetic risk assessment of nutritional pathways in preterm birth.
Authors:
Hans Christian Erichsen; Stephanie A Mulherin Engel; Peter K Eck; Robert Welch; Meredith Yeager; Mark Levine; Anna Maria Siega-Riz; Andrew F Olshan; Stephen J Chanock
Publication Detail:
Type:  Journal Article     Date:  2005-12-15
Journal Detail:
Title:  American journal of epidemiology     Volume:  163     ISSN:  0002-9262     ISO Abbreviation:  Am. J. Epidemiol.     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-01-20     Completed Date:  2006-03-06     Revised Date:  2011-01-21    
Medline Journal Info:
Nlm Unique ID:  7910653     Medline TA:  Am J Epidemiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  245-54     Citation Subset:  IM    
Affiliation:
Section on Genomic Variation, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
African Americans / genetics
Alleles
Ascorbic Acid / metabolism*
Case-Control Studies
European Continental Ancestry Group / genetics
Female
Genetic Variation*
Haplotypes
Humans
North Carolina
Organic Anion Transporters, Sodium-Dependent / genetics*
Polymorphism, Single Nucleotide*
Pregnancy
Premature Birth / genetics*
Risk Factors
Symporters / genetics*
Chemical
Reg. No./Substance:
0/Organic Anion Transporters, Sodium-Dependent; 0/Symporters; 0/sodium-dependent vitamin C transporter; 50-81-7/Ascorbic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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