| Genetic variation in pro-inflammatory cytokines and meningococcal sepsis. | |
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MedLine Citation:
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PMID: 20419848 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE OF REVIEW: Pro-inflammatory cytokines are an essential component of host defence in patients who are susceptible to meningococcal disease. This review summarizes what is currently known about genetic variations in genes encoding these defensive proteins and focuses on recent work investigating the potential role polymorphisms may play insusceptibility and severity of the disease. RECENT FINDINGS: A recently developed porcine model revealed significant cytokine derangement early in severe meningococcal sepsis raising the suggestion of a causative role for maladaptive cytokine release in the disease course. In patients who survive septic shock caused by the meningococcus there is a low innate production capacity for interleukin-1beta. Several polymorphisms have been identified in genes encoding for pro-inflammatory cytokines, and recently studies have shown association with susceptibility to infection in polymorphism at both IL-1RA (+2018) and TNF (-308). SUMMARY: Recent work is adding to the growing evidence that genetic variation in pro-inflammatory cytokines has a role in susceptibility and survival in meningococcal disease. However, data need to be interpreted with caution as there are many confounding factors, sample sizes are often small and there are challenges in identifying suitable control groups. |
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Authors:
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Alice Deasy; Robert C Read |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current opinion in infectious diseases Volume: 23 ISSN: 1473-6527 ISO Abbreviation: Curr. Opin. Infect. Dis. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-04-23 Completed Date: 2010-07-12 Revised Date: 2012-01-31 |
Medline Journal Info:
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Nlm Unique ID: 8809878 Medline TA: Curr Opin Infect Dis Country: United States |
Other Details:
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Languages: eng Pagination: 255-8 Citation Subset: IM |
Affiliation:
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Department of Infection & Immunity, Sheffield School of Medicine and Biomedical Science, Royal Hallamshire Hospital, Sheffield, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cytokines
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genetics*,
immunology* Genetic Predisposition to Disease Humans Meningococcal Infections / genetics*, immunology* Polymorphism, Genetic Sepsis / genetics*, immunology* |
| Chemical | |
Reg. No./Substance:
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0/Cytokines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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