| Genetic variation in TGF-beta 1 gene promoter and risk of gestational trophoblastic disease. | |
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MedLine Citation:
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PMID: 20506678 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To examine the relationship of transforming growth factor beta 1 (TGF-beta 1) gene polymorphisms at promoter positions -509 (C/T) and -800 (G/A) with the risk of gestational trophoblastic disease (GTD) as compared to normal controls STUDY DESIGN: Polymerase chain reaction-restriction fragment length polymorphism was performed on peripheral blood of 102 patients with GTD and 124 normal, healthy, pregnant women as the control group. RESULTS: In this study, TGF-beta 1 gene polymorphisms at positions -509 (C/T) and -800 (G/A) failed to correlate with GTD. CONCLUSION: Our findings suggest that promoter gene polymorphisms of TGF-beta 1 do not play major roles in GTD and may not be risk factors for this disease. |
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Authors:
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Alamtaj Samsami Dehaghani; Tarlan Zamanpour; Sirous Naeimi; Safoura Sameni; Minoo Robati; Abbas Ghaderi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of reproductive medicine Volume: 55 ISSN: 0024-7758 ISO Abbreviation: J Reprod Med Publication Date: 2010 Mar-Apr |
Date Detail:
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Created Date: 2010-05-28 Completed Date: 2010-07-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0173343 Medline TA: J Reprod Med Country: United States |
Other Details:
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Languages: eng Pagination: 151-6 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Shiraz University of Medical Sciences, Shiraz, Iran. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Case-Control Studies Female Gene Frequency Gestational Trophoblastic Neoplasms / genetics* Humans Polymerase Chain Reaction Polymorphism, Restriction Fragment Length* Pregnancy Promoter Regions, Genetic / genetics* Risk Transforming Growth Factor beta1 / genetics* |
| Chemical | |
Reg. No./Substance:
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0/Transforming Growth Factor beta1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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