| Genetic variation in TAS1R2 (Ile191Val) is associated with consumption of sugars in overweight and obese individuals in 2 distinct populations. | |
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MedLine Citation:
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PMID: 20943793 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Taste is an important determinant of food consumption, and genetic variations in the sweet taste receptor subunit TAS1R2 may contribute to interindividual variations in sugar consumption. OBJECTIVE: We determined whether Ser9Cys and Ile191Val variations in TAS1R2 were associated with differences in the consumption of sugars in 2 populations. DESIGN: Population 1 included 1037 diabetes-free young adults in whom we assessed dietary intake by using a 1-mo, 196-item food-frequency questionnaire. Population 2 consisted of 100 individuals with type 2 diabetes with dietary intakes assessed by using 2 sets of 3-d food records administered 2 wk apart. Dietary counseling was provided between food records 1 and 2. Dietary intakes between genotypes were compared by using analysis of covariance adjusted for potential confounders. RESULTS: In population 1, a significant Ile191Val × body mass index (BMI; in kg/m²) interaction was detected for the consumption of sugars, and the effect of genotype was significant only in individuals with a BMI ≥ 25 (n = 205). In comparison with individuals homozygous for the Ile allele, Val carriers consumed fewer sugars (122 ± 6 compared with 103 ± 6 g sugar/d, respectively; P = 0.01). Regression estimates that associated BMI with total sugar consumption by Ile/Ile and Val-carrier genotype intersected at a BMI of 23.5. In population 2, Val carriers also consumed less sugar than did individuals with the Ile/Ile genotype (99 ± 6 compared with 83 ± 6 g sugar/d, respectively; P = 0.04) on food record 2, and sugar was the only macronutrient that decreased significantly (-9 ± 4 g sugar/d, P = 0.02) in Val carriers who received dietary counseling. CONCLUSION: Our findings show that a genetic variation in TAS1R2 affects habitual consumption of sugars and may contribute to interindividual differences in changing behaviors in response to dietary counseling. |
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Authors:
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Karen M Eny; Thomas Ms Wolever; Paul N Corey; Ahmed El-Sohemy |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-10-13 |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 92 ISSN: 1938-3207 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-24 Completed Date: 2010-12-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 1501-10 Citation Subset: AIM; IM |
Affiliation:
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Department of Nutritional Sciences and the Dalla Lana School of Public Health, University of Toronto, Toronto, Canada. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Alleles Amino Acids / genetics Analysis of Variance Body Mass Index Diabetes Mellitus, Type 2 / genetics* Diet Records Dietary Sucrose / administration & dosage* Female Food Habits* Genotype Homozygote Humans Male Obesity / genetics* Overweight / genetics* Patient Education as Topic Polymorphism, Genetic* Questionnaires Receptors, G-Protein-Coupled / genetics* Reference Values Regression Analysis Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Dietary Sucrose; 0/Receptors, G-Protein-Coupled; 0/taste receptors, type 1 |
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