| Genetic variation in PNPLA3 but not APOC3 influences liver fat in NAFLD. | |
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MedLine Citation:
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PMID: 22141340 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background and Aim A recent study in 95 and 164 Indian subjects suggested common variants in APOC3 (T-455C at rs2854116 and C-482T at rs2854117) to contribute to NAFLD, plasma apoC3 and triglyceride concentrations. Our aim was to determine the contribution of genetic variation in APOC3 on liver fat content and plasma triglyceride and apoC3 concentrations in a larger European cohort. Methods 417 Finnish individuals were genotyped for rs2854116 and rs2854117 in APOC3 and the known rs738409 in PNPLA3 influencing liver fat. Plasma apoC3 concentration was measured enzymatically, and liver fat by (1) H-MRS. Results APOC3 wild-type homozygotes and variant allele (T-455C or C-482T or both) carriers did not differ with regard to liver fat, apoC3 concentrations, triglyceride-, HDL-, fasting plasma glucose, insulin-, ALT- and AST concentrations, nor was there a difference in prevalence of NAFLD. In contrast, carriers of the PNPLA3 GG genotype at rs738409 had a 2.7-fold (median 11.3%) higher liver fat than those with the CC (median 4.2%) genotype. The PNPLA3 rs738409 was also an independent predictor of liver fat, together with age, gender, and BMI. Conclusion Genetic variants in PNPLA3 but not APOC3 contribute to the variance in liver fat content due to NAFLD. |
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Authors:
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Jenni Hyysalo; Ivana Stojkovic; Anna Kotronen; Antti Hakkarainen; Ksenia Sevastianova; Janne Makkonen; Nina Lundbom; Aila Rissanen; Ronald M Krauss; Olle Melander; Marju Orho-Melander; Hannele Yki-Järvinen |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-6 |
Journal Detail:
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Title: Journal of gastroenterology and hepatology Volume: - ISSN: 1440-1746 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-6 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8607909 Medline TA: J Gastroenterol Hepatol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd. |
Affiliation:
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Department of Medicine, Division of Diabetes, University of Helsinki, Helsinki, Finland Minerva Medical Research Institute, Helsinki, Finland Department of Clinical Sciences, Diabetes and Endocrinology, University Hospital Malmö, Lund University, Malmö, Sweden Diabetes Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland Helsinki Medical Imaging Center, University of Helsinki, Helsinki, Finland Obesity Research Unit, Department of Psychiatry, University of Helsinki, Helsinki, Finland Children's Hospital Oakland Research Institute, Oakland, California. |
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