| Genetic variation in LIN28B is associated with the timing of puberty. | |
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MedLine Citation:
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PMID: 19448623 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The timing of puberty is highly variable. We carried out a genome-wide association study for age at menarche in 4,714 women and report an association in LIN28B on chromosome 6 (rs314276, minor allele frequency (MAF) = 0.33, P = 1.5 × 10(-8)). In independent replication studies in 16,373 women, each major allele was associated with 0.12 years earlier menarche (95% CI = 0.08-0.16; P = 2.8 × 10(-10); combined P = 3.6 × 10(-16)). This allele was also associated with earlier breast development in girls (P = 0.001; N = 4,271); earlier voice breaking (P = 0.006, N = 1,026) and more advanced pubic hair development in boys (P = 0.01; N = 4,588); a faster tempo of height growth in girls (P = 0.00008; N = 4,271) and boys (P = 0.03; N = 4,588); and shorter adult height in women (P = 3.6 × 10(-7); N = 17,274) and men (P = 0.006; N = 9,840) in keeping with earlier growth cessation. These studies identify variation in LIN28B, a potent and specific regulator of microRNA processing, as the first genetic determinant regulating the timing of human pubertal growth and development. |
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Authors:
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Ken K Ong; Cathy E Elks; Shengxu Li; Jing Hua Zhao; Jian'an Luan; Lars B Andersen; Sheila A Bingham; Soren Brage; George Davey Smith; Ulf Ekelund; Christopher J Gillson; Beate Glaser; Jean Golding; Rebecca Hardy; Kay-Tee Khaw; Diana Kuh; Robert Luben; Michele Marcus; Michael A McGeehin; Andrew R Ness; Kate Northstone; Susan M Ring; Carol Rubin; Matthew A Sims; Kijoung Song; David P Strachan; Peter Vollenweider; Gerard Waeber; Dawn M Waterworth; Andrew Wong; Panagiotis Deloukas; Inês Barroso; Vincent Mooser; Ruth J Loos; Nicholas J Wareham |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-05-17 |
Journal Detail:
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Title: Nature genetics Volume: 41 ISSN: 1546-1718 ISO Abbreviation: Nat. Genet. Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2010-09-20 Completed Date: 2010-11-04 Revised Date: 2013-04-29 |
Medline Journal Info:
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Nlm Unique ID: 9216904 Medline TA: Nat Genet Country: United States |
Other Details:
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Languages: eng Pagination: 729-33 Citation Subset: IM |
Affiliation:
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Medical Research Council (MRC) Epidemiology Unit, Addenbrooke's Hospital, Cambridge, UK. ken.ong@mrc-epid.cam.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Body Height Breast / growth & development Chromosomes, Human, Pair 6 / genetics* DNA-Binding Proteins / genetics* Female Genitalia / growth & development, physiology Hair / growth & development, physiology Humans Male Meta-Analysis as Topic MicroRNAs / genetics Mothers Polymorphism, Single Nucleotide Puberty / genetics* Regression Analysis |
| Grant Support | |
ID/Acronym/Agency:
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068049//Wellcome Trust; 068545/Z/02//Wellcome Trust; 076467/Z/05/Z//Wellcome Trust; 077011//Wellcome Trust; 077016//Wellcome Trust; 077016/Z/05/Z//Wellcome Trust; 079996//Wellcome Trust; 73437//Medical Research Council; G0000934//Medical Research Council; G0401527//Medical Research Council; G0401527(74922)//Medical Research Council; G0701863//Medical Research Council; MC_U106179471//Medical Research Council; MC_U106179472//Medical Research Council; U.1061.00.001 (79471)//Medical Research Council; U.1061.00.004(79472)//Medical Research Council; //Cancer Research UK |
| Chemical | |
Reg. No./Substance:
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0/DNA-Binding Proteins; 0/LIN28B protein, human; 0/MicroRNAs |
| Comments/Corrections | |
Comment In:
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Nat Genet. 2009 Jun;41(6):637-8
[PMID:
19471299
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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