Document Detail

Genetic variation in C-reactive protein in relation to colon and rectal cancer risk and survival.
MedLine Citation:
PMID:  20949557     Owner:  NLM     Status:  MEDLINE    
C-reactive protein (CRP), a biomarker of inflammation, has been shown to be influenced by genetic variation in the CRP gene. In this study, we test the hypothesis that genetic variation in CRP influences both the risk of developing colon and rectal cancer and survival. Two population-based studies of colon cancer (n = 1,574 cases, 1,970 controls) and rectal (n = 791 cases, 999 controls) were conducted. We evaluated four CRP tagSNPs: rs1205 (G > A, 3' UTR); rs1417938 (T > A, intron); rs1800947 (G > C, L184L); and rs3093075 (C > A, 3' flanking). The CRP rs1205 AA genotype was associated with an increased risk of colon cancer (OR 1.3, 95%CI 1.1-1.7), whereas the rs3093075 A allele was associated with a reduced risk of rectal cancer (OR 0.7, 95%CI 0.5-0.9). The strongest association for the rs1205 polymorphism and colon cancer was observed among those with KRAS2 mutations (OR 1.5, 95%CI 1.1-2.0). The CRP rs1205 AA genotype also was associated with an increased risk of CIMP+ rectal tumors (OR 2.5, 95%CI 1.2-5.3); conversely, the rs1417938 A allele was associated with a reduced risk of CIMP+ rectal tumors (OR 0.5, 95%CI 0.3-0.9). We observed interactions between CRP rs1800947 and BMI and family history of CRC in modifying risk of both colon and rectal cancer. These data suggest that genetic variation in the CRP gene influences risk of both colon and rectal cancer development.
Martha L Slattery; Karen Curtin; Elizabeth M Poole; David J Duggan; Wade S Samowitz; Ulrike Peters; Bette J Caan; John D Potter; Cornelia M Ulrich
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-11-28
Journal Detail:
Title:  International journal of cancer. Journal international du cancer     Volume:  128     ISSN:  1097-0215     ISO Abbreviation:  Int. J. Cancer     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-03-31     Completed Date:  2011-06-09     Revised Date:  2014-09-11    
Medline Journal Info:
Nlm Unique ID:  0042124     Medline TA:  Int J Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2726-34     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 UICC.
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MeSH Terms
C-Reactive Protein / genetics*
Case-Control Studies
Colonic Neoplasms / diagnosis,  genetics*,  mortality*
DNA, Neoplasm / genetics
Middle Aged
Polymerase Chain Reaction
Polymorphism, Single Nucleotide / genetics*
Rectal Neoplasms / diagnosis,  genetics*,  mortality*
Risk Factors
Survival Rate
Grant Support
CA85846/CA/NCI NIH HHS; N01-PC-35141/PC/NCI NIH HHS; R01 CA048998/CA/NCI NIH HHS; R01 CA048998-17/CA/NCI NIH HHS; R01 CA061757/CA/NCI NIH HHS; R01 CA061757-11/CA/NCI NIH HHS; R01 CA114467/CA/NCI NIH HHS; R01 CA48998/CA/NCI NIH HHS
Reg. No./Substance:
0/DNA, Neoplasm; 9007-41-4/C-Reactive Protein

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