| Genetic variation of the gamma subunit of the epithelial Na+ channel and essential hypertension. Relationship with salt sensitivity. | |
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MedLine Citation:
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PMID: 10912748 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We evaluated the association of a common polymorphism in gammaENaC, consisting in a C to G transversion in codon 649, with essential hypertension and to the pressor response to salt in whites. Two hundred fifteen essential hypertensive patients, and 137 normotensive controls were genotyped for the gamma649 ENaC polymorphism by polymerase chain reaction method and diagnostic restriction enzyme digestion. The genotype distribution of the gamma649 ENaC polymorphism in the hypertensives, 129 CC (60%) and 86 CG/GG (40%) was not significantly different from that of the control group, 84 CC (61%) and 53 CG/GG (39%) (P = .81). Salt sensitivity was assessed in a group of 48 patients by 24-h mean blood pressure response to changes in salt intake. Nineteen patients were diagnosed as salt sensitive, whereas 29 had salt-resistant hypertension. The gamma649 ENaC genotype distribution in salt-sensitive patients was 12 CC (63%) and 7 CG/GG (37%), not significantly different from the distribution in the salt-resistant group, 19 CC (65%) and 10 CG/GG (35%), P = .87. The changes in systolic, diastolic, and mean blood pressure as measured by ambulatory blood pressure monitoring, and in plasma renin activity and plasma aldosterone induced by high salt diet were not different among the gamma649 ENaC genotypes. In the present study we found no association between the gamma649 ENaC polymorphism and essential hypertension or salt sensitivity. Although these data do not support a major causative role for this polymorphism, we cannot exclude that a functional mutation elsewhere in ENaC might be associated with essential hypertension. |
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Authors:
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E Poch; D González; A de la Sierra; V Giner; E Bragulat; A Botey; A Coca; F Rivera |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of hypertension Volume: 13 ISSN: 0895-7061 ISO Abbreviation: Am. J. Hypertens. Publication Date: 2000 Jun |
Date Detail:
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Created Date: 2000-11-02 Completed Date: 2000-11-21 Revised Date: 2009-02-24 |
Medline Journal Info:
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Nlm Unique ID: 8803676 Medline TA: Am J Hypertens Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 648-53 Citation Subset: IM |
Affiliation:
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Servicio de Nefrología, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Hospital Clínic, Universidad de Barcelona, Spain. epoch@medicina.ub.es |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aldosterone / blood Blood Pressure / drug effects*, genetics, physiology Blood Pressure Monitoring, Ambulatory DNA / analysis* DNA Primers / chemistry Epithelial Sodium Channel Female Genetic Predisposition to Disease Genotype Humans Hypertension / blood, genetics*, physiopathology Male Middle Aged Point Mutation Polymerase Chain Reaction Polymorphism, Genetic* Renin / blood Sodium Channels / blood, genetics* Sodium, Dietary / adverse effects* |
| Chemical | |
Reg. No./Substance:
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0/DNA Primers; 0/Epithelial Sodium Channel; 0/Sodium Channels; 0/Sodium, Dietary; 52-39-1/Aldosterone; 9007-49-2/DNA; EC 3.4.23.15/Renin |
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