Document Detail


Genetic variation of dietary restriction and the effects of nutrient-free water and amino acid supplements on lifespan and fecundity of Drosophila.
MedLine Citation:
PMID:  21767463     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
SummaryWe measure genetic variation in lifespan and fecundity at two food levels in 34 core lines of the Drosophila Genetic Reference Panel collection. Lines were significantly different from each other in lifespan and fecundity at both restricted and full food. There was a strong food-by-line interaction for the slope of age-specific mortality, fecundity and proportion of fertilized eggs, indicating the presence of genetic variation for the strength of the dietary restriction effect, likely to represent standing genetic variation in a natural population from which the lines used have originated. No trade-off between fecundity and lifespan manifested in life-history variation among inbred lines. Our data partially corroborate the recent proposition that availability of nutrient-free water eliminates the apparent dietary restriction at least in some conditions. Although flies on full food with water added had lifespan slightly higher than those without a water source, it was still significantly lower than that in flies on restricted food, with no indication of interaction. We fully corroborate the recently discovered effect of addition of essential amino acids to the medium: addition of 1·5 mM methionine to restricted food significantly increased fecundity without a measurable decrease in lifespan; addition of each of 10 essential amino acids increased fecundity and decreased females lifespan to the levels observed on full food, again with no evidence of line-by-food interactions. We propose a mechanistic hypothesis explaining the observed data, based on the assumption that food consumption by flies is adjusted according to flies' saturation in water and methionine.
Authors:
Kenneth B Dick; Chelsea R Ross; Lev Y Yampolsky
Related Documents :
22200413 - Time spent in home meal preparation affects energy and food group intakes among midlife...
21920063 - The fake food buffet - a new method in nutrition behaviour research.
3571613 - Performance of lactating dairy cows fed silage from corn of varying maturities.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-7-18
Journal Detail:
Title:  Genetics research     Volume:  -     ISSN:  1469-5073     ISO Abbreviation:  -     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-7-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101550220     Medline TA:  Genet Res (Camb)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1-9     Citation Subset:  -    
Affiliation:
Department of Biological Sciences, East Tennessee State University, Johnson City, TN 37614-1710, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Genetic analysis of tolerance to infections using random regressions: a simulation study.
Next Document:  Aging in Rural Canada: A Retrospective and Review.