| Genetic variation of IL-12B (+1188 region) is associated with its decreased circulating levels and susceptibility to Type 2 diabetes. | |
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MedLine Citation:
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PMID: 22296201 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Background: Type 2 diabetes mellitus is one of the most common types of endocrine disease and the immune system plays a predominant role in its pathogenesis. Aims: The present study aimed to examine known gene polymorphisms within IL-12B (+1188) region and its circulating serum levels in Type 2 diabetic patients from the southeastern region of Iran and compare them with unrelated controls. Materials & methods: In this clinical study, peripheral blood was collected from 114 Type 2 diabetic patients and 100 healthy controls. Serum levels of IL-12B were measured by ELISA. Genomic DNA was extracted from peripheral blood samples and polymorphisms at the +1188 position of the IL-12B gene were assessed using PCR restriction fragment-length polymorphism. Results: Our findings demonstrated that the AA genotype and the A allele of IL-12B were increased significantly in Type 2 diabetic patients when compared with controls. Our results also showed that the circulating levels of IL-12B were significantly decreased in Type 2 diabetic patients when compared with controls. Conclusion: According to the findings of the current study, we concluded that IL-12B and its +1188 polymorphism may play a prominent role in the pathogenesis of Type 2 diabetes. Further replicative investigations using a larger sample size are essential to identify additional IL-12B genetic variants associated with a risk of Type 2 diabetes. |
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Authors:
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Narges Yaghini; Mehdi Mahmoodi; Gholamhossein Hassanshahi; Gholamreza Asadikaram; Mohammad Kazemi Arababadi; Mohsen Rezaeian; Seyed Mohammad Ali Sajjadi; Derek Kennedy |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biomarkers in medicine Volume: 6 ISSN: 1752-0371 ISO Abbreviation: Biomark Med Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-02-02 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101312535 Medline TA: Biomark Med Country: England |
Other Details:
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Languages: eng Pagination: 89-95 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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