| Genetic variants in RUNX3 and risk of bladder cancer: a haplotype-based analysis. | |
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MedLine Citation:
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PMID: 18684727 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Transforming growth factor-beta (TGF-beta) is a multifunctional growth factor that plays important roles in many biological processes, whereas RUNX3 is a target of TGF-beta-mediated tumor suppressor pathway. In humans, RUNX3 inactivation may lead to the cancer development, including bladder cancer. To determine whether the RUNX3 polymorphisms are associated with risk of bladder cancer, we conducted a case-control study of 368 bladder cancer patients and 368 cancer-free controls to assess the associations between the RUNX3 tagging single-nucleotide polymorphisms (tSNPs) and bladder cancer risk. In the single-locus analysis, we found a significantly increased risk of bladder cancer associated with the SNP7 rs760805 AA genotype (adjusted odds ratio = 1.97, 95% confidence interval = 1.44-2.69), compared with the AT/TT genotype. Haplotype-based association analysis revealed that the increased risk of bladder cancer was significantly associated with two haplotypes TATCCCAAAA (2.37, 1.16-4.83) and AGCTTGAGAG (2.70, 1.08-6.72) that included the rs760805 A allele. Multifactor dimensionality reduction (MDR) analysis identified a significant more than multiplicative interaction between the SNP7 rs760805 AA and smoking and an additive interaction between the SNP3 rs11249206 TT and smoking on bladder cancer risk. The SNP3 rs11249206, SNP5 rs1395621, SNP7 rs760805, SNP8 rs2236852 and the trichotomized cumulative smoking were the five factors best predicted by the MDR models. When the variables were combined and dichotomized and fitted into the MDR model, the subjects carrying the combined risk stratum had a significantly increased risk for bladder cancer (6.37, 4.57-8.87, P = 7.03 x 10(-28)). These results suggested that the genetic variants in RUNX3 may modulate the risk of bladder cancer. |
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Authors:
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Zhizhong Zhang; Shizhi Wang; Meilin Wang; Na Tong; Guangbo Fu; Zhengdong Zhang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-08-05 |
Journal Detail:
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Title: Carcinogenesis Volume: 29 ISSN: 1460-2180 ISO Abbreviation: Carcinogenesis Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-10-02 Completed Date: 2008-10-14 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8008055 Medline TA: Carcinogenesis Country: England |
Other Details:
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Languages: eng Pagination: 1973-8 Citation Subset: IM |
Affiliation:
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Cancer Center, Department of Molecular and Genetic Toxicology, Nanjing Medical University, Nanjing 210029, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Case-Control Studies Core Binding Factor Alpha 3 Subunit / genetics* Female Genetic Predisposition to Disease Genetic Variation Genotype Haplotypes Humans Male Middle Aged Polymorphism, Single Nucleotide* Risk Smoking / adverse effects Urinary Bladder Neoplasms / etiology, genetics* |
| Chemical | |
Reg. No./Substance:
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0/Core Binding Factor Alpha 3 Subunit; 0/Runx3 protein, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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