| Genetic variants in the 8q24 locus and risk of testicular germ cell tumors. | |
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MedLine Citation:
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PMID: 18373104 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Much evidence supports the premise that population genetic variation contributes significantly to the risk of testicular germ-cell tumor (TGCT). However, investigations of the association between genomic markers and TGCT susceptibility are scarce. Single nucleotide polymorphisms (SNPs) at the locus 8q24 have recently been found to be associated with prostate, colorectal and breast cancer. The US Servicemen's testicular tumor environmental and endocrine determinants (STEED) study was used to investigate the association of 15 specific 8q24 SNPs with TGCT and its two main histologic groups of seminoma and nonseminoma. Conditional and unconditional logistic regression models, adjusted for the matching variables of year of birth, race/ethnicity and serum date, were utilized to produce odds ratios (OR) and 95% confidence intervals (95%CI). The analysis included 680 controls and 568 TGCT cases. In the TGCT analysis, no SNP was associated with risk in both heterozygotes and variant homozygotes. When stratified by histology the seminoma analysis also showed no association with the 8q24 SNPs. Conversely, the analysis of nonseminomas had three tentative associations (rs6470494, OR(genotype AG) = 1.15, 95%CI: 0.86-1.54; OR(genotype GG) = 1.68, 95%CI: 1.04-2.73; p for trend = 0.04) (rs13254738, OR(genotype GT) = 1.04, 95%CI: 0.77-1.40; OR(genotype TT) = 1.62, 95%CI: 1.06-2.49; p for trend = 0.07) (rs10505476, OR(genotype CT) = 0.67, 95%CI: 0.50, 0.91; OR(genotype TT) = 0.81, 95%CI: 0.47-1.39; p for trend = 0.04). There was no linkage disequilibrium between any of the 8q24 SNPs analyzed in this population. In conclusion, this study has found little evidence for an association between the reported 8q24 SNPs and TGCTs, although the findings for nonseminoma may be worth further investigation. |
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Authors:
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Michael B Cook; Barry I Graubard; Sabah M Quraishi; Meredith Yeager; Stephen J Chanock; Andrew Crenshaw; Ralph L Erickson; Mark V Rubertone; Gilles Thomas; Katherine A McGlynn |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Intramural Date: 2008-03-29 |
Journal Detail:
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Title: Human genetics Volume: 123 ISSN: 1432-1203 ISO Abbreviation: Hum. Genet. Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-04-16 Completed Date: 2008-04-29 Revised Date: 2012-03-07 |
Medline Journal Info:
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Nlm Unique ID: 7613873 Medline TA: Hum Genet Country: Germany |
Other Details:
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Languages: eng Pagination: 409-18 Citation Subset: IM |
Affiliation:
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Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892-7234, USA. cookmich@mail.nih.gov |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Case-Control Studies Chromosomes, Human, Pair 8 / genetics* Genetic Variation* Humans Linkage Disequilibrium Male Middle Aged Neoplasms, Germ Cell and Embryonal / genetics* Polymorphism, Single Nucleotide Risk Factors Seminoma / genetics Testicular Neoplasms / genetics* |
| Grant Support | |
ID/Acronym/Agency:
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Z99 CA999999/CA/NCI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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