| Genetic variants affecting incretin sensitivity and incretin secretion. | |
| | |
MedLine Citation:
|
PMID: 20714888 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Recent genome-wide association studies identified several novel risk genes for type 2 diabetes. The majority of these type 2 diabetes risk variants confer impaired pancreatic beta cell function. Though the molecular mechanisms by which common genetic variation within these loci affects beta cell function are not completely understood, risk variants may alter glucose-stimulated insulin secretion, proinsulin conversion, and incretin signals. In humans, the incretin effect is mediated by the secretion and insulinotropic action of two peptide hormones, glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1. This review article aims to give an overview of the type 2 diabetes risk loci that were found to associate with incretin secretion or incretin action, paying special attention to the potential underlying mechanisms. |
| | |
Authors:
|
K Müssig; H Staiger; F Machicao; H-U Häring; A Fritsche |
Related Documents
:
|
7323698 - Glucose-induced release of immunoreactive gastric inhibitory polypeptide (ir-gip) into ... 6146198 - The hormonal changes produced by duodenogastric reflux. 16720628 - Exogenously imposed postprandial-like rises in systemic glucose and glp-1 do not produc... 955338 - Gastric inhibitory polypeptide (gip), gastrin and insulin: response to test meal in coe... 22528288 - Integrating diabetes self-management interventions for mexican-americans into the catho... 2524588 - Activation of heart sarcoplasmic reticulum ca++-stimulated adenosine triphosphatase by ... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2010-08-17 |
Journal Detail:
|
Title: Diabetologia Volume: 53 ISSN: 1432-0428 ISO Abbreviation: Diabetologia Publication Date: 2010 Nov |
Date Detail:
|
Created Date: 2010-09-29 Completed Date: 2011-01-18 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0006777 Medline TA: Diabetologia Country: Germany |
Other Details:
|
Languages: eng Pagination: 2289-97 Citation Subset: IM |
Affiliation:
|
Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Department of Internal Medicine, Eberhard Karls University, 72076, Tübingen, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Diabetes Mellitus, Type 2 / genetics, metabolism* Gastric Inhibitory Polypeptide / metabolism Genome-Wide Association Study Glucagon-Like Peptide 1 / metabolism Humans Incretins / metabolism*, secretion* Insulin-Secreting Cells / metabolism, pathology |
| Chemical | |
Reg. No./Substance:
|
0/Incretins; 59392-49-3/Gastric Inhibitory Polypeptide; 89750-14-1/Glucagon-Like Peptide 1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Characterization of protein in old myocardial infarction by FTIR micro-spectroscopy.
Next Document: Evaluation of standard and advanced preprocessing methods for the univariate analysis of blood serum...