| Genetic variability of matrix metalloproteinase genes in cardiovascular disease. | |
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MedLine Citation:
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PMID: 22519450 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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It is well established that matrix metalloproteinases (MMPs) contribute to the degradation of the extracellular matrix of coronary plaque and contribute to the thinning of the fibrous cap. As a result, the atheromatous plaque becomes unstable and prone to rupture with consequent clinical manifestations including acute coronary syndromes. Moreover, genetic polymorphisms of MMPs have been found to be associated with the concentration of circulating MMPs, and over the past few decades, considerable efforts have been devoted to explore the relationships between MMPs polymorphisms and myocardial infarction risk among various populations. However, existing studies have yielded inconsistent results. Some observations have suggested that genetic variation that affects the expression of MMPs may contribute to the occurrence of myocardial infarction, whereas others reported no support for an association of MMPs polymorphisms with myocardial infarction susceptibility. Furthermore, the interpretation of these studies has been complicated by the use of different populations or different control sources. Therefore, further studies are required to evaluate the role of matrix metalloproteinases and especially the associated genetic polymorphisms in cardiovascular disease. |
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Authors:
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Nikolaos Papageorgiou; Dimitris Tousoulis; George Hatzis; Alexandros Briasoulis; Emmanuel Androulakis; Anastasios Giolis; Gerasimos Siasos; George Latsios; Georgia Vogiatzi; Costas Tentolouris; Christodoulos Stefanadis |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-4-20 |
Journal Detail:
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Title: Current topics in medicinal chemistry Volume: - ISSN: 1873-4294 ISO Abbreviation: - Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-4-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101119673 Medline TA: Curr Top Med Chem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1st Cardiology Department, Hippokration Hospital Athens University Medical School Athens, Greece. drnpapageorgiou@yahoo.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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