Document Detail


Genetic variability in response to infection: malaria and after.
MedLine Citation:
PMID:  12209359     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recent studies have shown that the relatively short period of exposure of human populations to malaria has left in its wake a wide range of genetic diversity. And there is growing evidence that other infectious agents have, or are, having the same effect. By integrating further studies of human populations with genetic analyses of susceptibility to murine malaria it should now be possible to determine some of the mechanisms involved in the variation of susceptibility to infectious disease, information which may have important practical implications for both the diagnosis and better management of these conditions.
Authors:
D J Weatherall; J B Clegg
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Genes and immunity     Volume:  3     ISSN:  1466-4879     ISO Abbreviation:  Genes Immun.     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2002-09-04     Completed Date:  2003-05-07     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  100953417     Medline TA:  Genes Immun     Country:  England    
Other Details:
Languages:  eng     Pagination:  331-7     Citation Subset:  IM    
Affiliation:
Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK. david.weatherall@imm.ox.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Animals
Disease Models, Animal
Erythrocytes / physiology*
Evolution
Genetic Diseases, Inborn*
Genetic Variation
HLA Antigens / genetics
Hemoglobins / genetics*
Humans
Infection / genetics
Malaria / genetics*
Mice
Chemical
Reg. No./Substance:
0/HLA Antigens; 0/Hemoglobins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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