Document Detail


Genetic variability of apolipoprotein E in a Polish population.
MedLine Citation:
PMID:  9825598     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Apolipoprotein E (apoE, protein; APOE, gene) is a component of very low density lipoprotein and high-density lipoprotein and plays an important role in lipoprotein metabolism. There are three common alleles of APOE (*2, *3, and *4), which encode the E2, E3, and E4 isoforms of the protein. Distribution of apoE isoforms shows marked variation among various ethnic groups. Direct phenotyping of human APOE in plasma was used to estimate APOE allele frequencies in 137 unrelated blood donors from 3 regions of Poland. The relative frequencies observed for the APOE*2, APOE*3, and APOE*4 alleles were 0.055, 0.839, and 0.106, respectively. The data have been compared with data found in other population groups. The frequency of the APOE*2 allele in Poles was among the lowest in Europe.
Authors:
A Kowalska; I Wiechmann; H Walter
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article    
Journal Detail:
Title:  Human biology     Volume:  70     ISSN:  0018-7143     ISO Abbreviation:  Hum. Biol.     Publication Date:  1998 Dec 
Date Detail:
Created Date:  1998-12-15     Completed Date:  1998-12-15     Revised Date:  2011-04-18    
Medline Journal Info:
Nlm Unique ID:  0116717     Medline TA:  Hum Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1093-9     Citation Subset:  IM    
Affiliation:
Institute of Human Genetics, Polish Academy of Sciences, Poznań, Poland.
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MeSH Terms
Descriptor/Qualifier:
Adult
Alleles
Apolipoproteins E / blood,  genetics*
Europe
European Continental Ancestry Group / genetics
Female
Gene Frequency*
Humans
Male
Phenotype
Poland
Reference Values
Chemical
Reg. No./Substance:
0/Apolipoproteins E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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