Document Detail


Genetic toxicity assessment: employing the best science for human safety evaluation part VI: when salt and sugar and vegetables are positive, how can genotoxicity data serve to inform risk assessment?
MedLine Citation:
PMID:  17387098     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This opinion piece examines the current approaches in the design and evaluation of genotoxicity data and recommends an alternative that would provide information that could be more useful to human risk assessment. It is suggested that genotoxicity studies, both in vitro and in vivo, be designed similar to other traditional toxicology studies, such that a dose-response relationship is characterized, including identification of a "no-observed-adverse-effect-level" dose. It is further suggested that genotoxicity tests should no longer be designed or interpreted in isolation but should be examined in the context of other available data including toxicokinetics, mechanism of genotoxicity, and relevant exposure information. The answer to improving genetic toxicology testing does not lie in coming up with better, "more sensitive" genotoxicity test systems but rather in the incorporation of contextual improvements in both the experimental design and the interpretation of data collected using the current models. Such a strategy will better position the toxicology and risk assessment communities to cope with the current intellectually uncomfortable dichotomy that directs disproportionate scientific resource to addressing genetic toxicity findings of anthropogenic substances, regardless of dose-exposure context, while at the same time ignoring the plethora and comparatively large amounts of genotoxic and toxic substances that are inescapably present in what are otherwise regarded as healthy foods (salt, sugar, and vegetables).
Authors:
Lynn H Pottenger; James S Bus; B Bhaskar Gollapudi
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Publication Detail:
Type:  Journal Article     Date:  2007-03-25
Journal Detail:
Title:  Toxicological sciences : an official journal of the Society of Toxicology     Volume:  98     ISSN:  1096-6080     ISO Abbreviation:  Toxicol. Sci.     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-07-19     Completed Date:  2007-09-19     Revised Date:  2010-09-17    
Medline Journal Info:
Nlm Unique ID:  9805461     Medline TA:  Toxicol Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  327-31     Citation Subset:  IM    
Affiliation:
Toxicology and Environmental Research and Consulting, The Dow Chemical Company, Midland, Michigan 48674, USA. lpottenger@dow.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Dietary Sucrose / toxicity
Humans
Mutagenicity Tests*
Mutagens / toxicity*
No-Observed-Adverse-Effect Level
Risk Assessment
Sodium Chloride / toxicity
Vegetables / toxicity
Chemical
Reg. No./Substance:
0/Dietary Sucrose; 0/Mutagens; 7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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