| Genetic thromobophilia in pregnancy: a case-control study among North Indian women. | |
| | |
MedLine Citation:
|
PMID: 22918664 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
In the present study, an attempt is made to understand the role of genetic thrombophilias i.e. MTHFR C677T and FVL in the causation of various pregnancy complications like pregnancy induced hypertension (PIH), recurrent abortions, intra-uterine growth retardation (IUGR) and intra-uterine death on the whole and also individually along with the comparative assessment of pathophysiological basis of various pregnancy complications via the genetic proximities. One thousand and eleven (1,011) women of reproductive age group were recruited in the present study comprising various complications and controls. Recruitment criteria for all the pregnancy complications and controls was made and followed strictly. MTHFR C677T and FVL mutation detection was done in all the subjects. Vegetarianism was found to be significant risk factors for all the pregnancy complications and also when assessed individually. With respect to MTHFR C677T polymorphism, higher frequency of 677T allele was found among controls as compared to cases. 677T allele was found to pose decreased risk for various pregnancy complications on the whole and also individually. On adjusting the diet, regression analysis revealed no risk of mutant allele (T) for various pregnancy complications. FVL homozygous mutants were found to be absent among controls. In conclusion, the present study depicts dietary pattern as one of the most important factors in demonstrating the role of MTHFR C677T in various pregnancy complications and is indicative of a relatively deleterious effect of double dose of FVL in the presently studied population. Additionally, these polymorphisms play an important role in the orchestration of PIH to IUGR and vice versa. |
| | |
Authors:
|
Lovejeet Kaur; Manju Puri; Shweta Kaushik; Mohinder Pal Sachdeva; Shubha Sagar Trivedi; Kallur Nava Saraswathy |
Related Documents
:
|
8905894 - The influence of the experience of the investigator on the rate of sonographic diagnosi... 9201874 - Early sonographic diagnosis of jarcho-levin syndrome: a prospective screening program i... 17619094 - Ultrasound screening for fetal abnormality in ireland: a national survey. 100524 - Rare occurrence of a holoacardious acephalic monster: sonographic and pathologic findings. 18329024 - Ongoing twin pregnancy after rescue intracytoplasmic sperm injection of unfertilized ab... 2606954 - Oocyte donation by gamete intra-fallopian transfer to amenorrhoeic and cycling patients... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-8-24 |
Journal Detail:
|
Title: Journal of thrombosis and thrombolysis Volume: - ISSN: 1573-742X ISO Abbreviation: J. Thromb. Thrombolysis Publication Date: 2012 Aug |
Date Detail:
|
Created Date: 2012-8-24 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9502018 Medline TA: J Thromb Thrombolysis Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Anthropology, University of Delhi, Delhi, India. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Influence of IL-6 haplotypes on clinical and inflammatory response in aggressive periodontitis.
Next Document: An Inverse Problem Approach to Recovery of In Vivo Nanoparticle Concentrations from Thermal Image Mo...