| Genetic threshold hypothesis of neocortical spike-and-wave discharges in the rat: an animal model of petit mal epilepsy. | |
| | |
MedLine Citation:
|
PMID: 7485236 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Neocortical high-voltage spike-and-wave discharges (HVS) in the rat are an animal model of petit mal epilepsy. Genetic analysis of total duration of HVS (s/12 hr) in reciprocal F1 and F2 hybrids of F344 and BN rats indicated that the phenotypic variability of HVS cannot be explained by a simple, monogenic Mendelian model. Biometrical analysis suggested the presence of additive, dominance, and sex-linked-epistatic effects, buffering maternal influence, and heterosis. High correlation was observed between average duration (s/episode) and frequency of occurrence of spike-and-wave episodes (n/12 hr) in parental and segregating generations, indicating that common genes affect both duration and frequency of the spike-and-wave pattern. We propose that both genetic and developmental-environmental factors control an underlying quantitative variable, which, above a certain threshold level, precipitates HVS discharges. These findings, together with the recent availability of rat DNA markers for total genome mapping, pave the way to the identification of genes that control the susceptibility of the brain to spike-and-wave discharges. |
| | |
Authors:
|
C Vadász; D Carpi; G Jando; A Kandel; R Urioste; Z Horváth; E Pierre; D Vadi; A Fleischer; G Buzsáki |
Related Documents
:
|
891806 - Effects of electrical stimulation of periaqueductal gray matter on evoked potentials re... 12122066 - Relations between brain pathology and temporal lobe epilepsy. 1760726 - Effects of intra-amygdaloid injections of alpha-difluoromethylornithine and putrescine ... 2887246 - Somatostatin-like immunoreactivity (sli) in cisternal cerebrospinal fluid of rats kindl... 9267656 - Vernier and grating acuity in adult hooded rats: the influence of sex. 1157876 - Ultrastructural evidence of a secretory process in the rat pineal gland. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: American journal of medical genetics Volume: 60 ISSN: 0148-7299 ISO Abbreviation: Am. J. Med. Genet. Publication Date: 1995 Feb |
Date Detail:
|
Created Date: 1995-12-15 Completed Date: 1995-12-15 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 7708900 Medline TA: Am J Med Genet Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 55-63 Citation Subset: IM |
Affiliation:
|
Laboratory of Neurobehavioral Genetics, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Action Potentials
/
genetics Animals Cerebral Cortex / physiopathology Crosses, Genetic Disease Models, Animal Electroencephalography Electrophysiology Epilepsy, Absence / genetics*, physiopathology Female Humans Male Models, Genetic* Rats Rats, Inbred BN Rats, Inbred F344 Sex Characteristics |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Chromosomal abnormalities in a psychiatric population.
Next Document: Quantitative genetic analysis of injury liability in infants and toddlers.