Document Detail

Genetic targeting of the renin-angiotensin system for long-term control of hypertension.
MedLine Citation:
PMID:  11790288     Owner:  NLM     Status:  MEDLINE    
Although traditional approaches are effective for the treatment and control of hypertension, they have not succeeded in curing the disease, and have therefore reached a plateau. As a result of the completion of the Human Genome Project and the continuous advancement in gene delivery systems, it is now possible to investigate genetic means for the treatment and possible cure for hypertension. In this review we discuss the potential of genetic targeting of the renin-angiotensin system for the treatment of hypertension. We provide examples of various approaches that have used antisense technology with a high degree of success. We focus on our own research, which targets the use of antisense of the angiotensin type I receptor in various models of hypertension. Finally, we discuss the future of antisense technology in the treatment of human hypertension.
Beverly L Metcalfe; Mohan Raizada; Michael J Katovich
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current hypertension reports     Volume:  4     ISSN:  1522-6417     ISO Abbreviation:  Curr. Hypertens. Rep.     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-01-15     Completed Date:  2002-04-10     Revised Date:  2006-07-12    
Medline Journal Info:
Nlm Unique ID:  100888982     Medline TA:  Curr Hypertens Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  25-31     Citation Subset:  IM    
Department of Pharmacodynamics, University of Florida, College of Pharmacy, PO Box 100487, Gainesville, FL 32610-0487, USA.
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MeSH Terms
Blood Pressure / physiology
Gene Targeting
Gene Therapy*
Hypertension / genetics,  prevention & control,  therapy*
Myocardium / metabolism
Oligonucleotides, Antisense / therapeutic use*
Receptor, Angiotensin, Type 1
Receptors, Angiotensin / biosynthesis*
Renin-Angiotensin System / genetics*
Reg. No./Substance:
0/Oligonucleotides, Antisense; 0/Receptor, Angiotensin, Type 1; 0/Receptors, Angiotensin

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