| Genetic syndromic immunodeficiencies with antibody defects. | |
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MedLine Citation:
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PMID: 18940571 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This article reviews the major syndromic immunodeficiencies with significant antibody defects, many of which may require intravenous immunogammaglobulin therapy. The authors define syndromic immunodeficiency as an illness associated with a characteristic group of phenotypic abnormalities or laboratory features that comprise a recognizable syndrome. Many are familial with a defined inheritance pattern. Immunodeficiency may not be a major part of the illness and may not be present in all patients; thus, these conditions differ from primary immunodeficiency syndromes, in which immune abnormalities are a consistent and prominent feature of their disease. |
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Authors:
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Jeffrey E Ming; E Richard Stiehm |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Immunology and allergy clinics of North America Volume: 28 ISSN: 0889-8561 ISO Abbreviation: Immunol Allergy Clin North Am Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2008-10-22 Completed Date: 2009-02-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8805635 Medline TA: Immunol Allergy Clin North Am Country: United States |
Other Details:
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Languages: eng Pagination: 715-36, vii Citation Subset: IM |
Affiliation:
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Division of Human Genetics, Department of Pediatrics, The Children's Hospital of Philadelphia, The University of Pennsylvania School of Medicine, 3615 Civic Center Boulevard, Philadelphia, PA 19104, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Body Size
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genetics,
immunology* Congenital Abnormalities / genetics, immunology* Humans Immunization, Passive Immunoglobulins / deficiency, genetics Immunoglobulins, Intravenous / therapeutic use Immunologic Deficiency Syndromes / diagnosis, genetics, immunology*, physiopathology, therapy Mutation Organ Specificity Pedigree |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulins; 0/Immunoglobulins, Intravenous |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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