| Genetic susceptibility to infection-mediated preterm birth. | |
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MedLine Citation:
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PMID: 18954761 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Preterm birth is a heterogeneous disorder that is responsible for significant neonatal morbidity and mortality. Intrauterine infection is implicated in a significant proportion of preterm birth-particularly in early gestation. Epidemiologic evidence supports a genetic component to infection overall and preterm birth in particular. Furthermore, a number of studies examining genes involved in pathogen recognition and our response to pathogens suggest a genetic susceptibility to infection-mediated preterm birth. On the whole, however, these studies have been difficult to replicate and explain only a small portion of the phenotypic variation in preterm birth. Given this, methodological considerations are emphasized to improve our understanding of the genetic susceptibility to infection-mediated preterm birth. |
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Authors:
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Katherine P Himes; Hyagriv N Simhan |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Infectious disease clinics of North America Volume: 22 ISSN: 0891-5520 ISO Abbreviation: Infect. Dis. Clin. North Am. Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-10-28 Completed Date: 2009-01-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8804508 Medline TA: Infect Dis Clin North Am Country: United States |
Other Details:
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Languages: eng Pagination: 741-53, vii Citation Subset: IM |
Affiliation:
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Division of Maternal Fetal Medicine, University of Pittsburgh Medical Center, Magee-Womens Hospital, Pittsburgh, PA 15213, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Female Genetic Predisposition to Disease* Gestational Age Humans Infection / complications*, epidemiology, etiology, genetics* Pregnancy Premature Birth / epidemiology, etiology*, genetics* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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